| 1 |
EcoR1 Capital, LLC |
2,098,302 |
10,533,000 |
18.29% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
2,039,505 |
10,238,000 |
17.78% |
|
|
| 3 |
Visium Asset Management, LP |
1,709,992 |
8,584,000 |
14.91% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
1,397,100 |
7,013,000 |
12.18% |
|
|
| 5 |
QVT Financial LP |
740,700 |
3,049,000 |
5.30% |
|
|
| 6 |
VANGUARD GROUP INC |
471,134 |
2,365,000 |
4.11% |
|
|
| 7 |
Rock Springs Capital Management LP |
390,000 |
1,958,000 |
3.40% |
|
|
| 8 |
BlackRock Fund Advisors |
381,422 |
1,915,000 |
3.33% |
|
|
| 9 |
PUTNAM INVESTMENTS LLC |
370,000 |
1,857,000 |
3.22% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
364,467 |
1,830,000 |
3.18% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
334,732 |
1,680,000 |
2.92% |
|
|
| 12 |
BAKER BROS. ADVISORS LP |
250,000 |
1,255,000 |
2.18% |
|
|
| 13 |
NORTHERN TRUST CORP |
175,269 |
880,000 |
1.53% |
|
|
| 14 |
STATE STREET CORP |
158,273 |
799,000 |
1.39% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
87,719 |
440,000 |
0.76% |
|
|
| 16 |
DIALECTIC CAPITAL MANAGEMENT, LP |
56,862 |
286,000 |
0.50% |
|
|
| 17 |
BlackRock Investment Management, LLC |
52,755 |
265,000 |
0.46% |
|
|
| 18 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
51,282 |
257,000 |
0.45% |
|
|
| 19 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
48,976 |
246,000 |
0.43% |
|
|
| 20 |
Bank of New York Mellon Corp |
45,829 |
230,000 |
0.40% |
|
|
| 21 |
DIMENSIONAL FUND ADVISORS LP |
41,459 |
208,000 |
0.36% |
|
|
| 22 |
BLAIR WILLIAM & CO/IL |
40,850 |
205,000 |
0.36% |
|
|
| 23 |
RENAISSANCE TECHNOLOGIES LLC |
31,800 |
160,000 |
0.28% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
30,786 |
155,000 |
0.27% |
|
|
| 25 |
D. E. Shaw & Co., Inc. |
24,928 |
125,000 |
0.22% |
|
|
| 26 |
CAXTON CORP |
22,185 |
111,000 |
0.19% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
21,201 |
106,000 |
0.18% |
|
|
| 28 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
20,668 |
104,000 |
0.18% |
|
|
| 29 |
B. Riley Wealth Advisors, Inc. |
19,757 |
99,000 |
0.17% |
|
|
| 30 |
DEUTSCHE BANK AG\ |
14,790 |
73,000 |
0.13% |
|
|
| 31 |
RHUMBLINE ADVISERS |
14,209 |
71,000 |
0.12% |
|
|
| 32 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
13,328 |
67,000 |
0.12% |
|
|
| 33 |
NEW YORK STATE COMMON RETIREMENT FUND |
13,100 |
66,000 |
0.11% |
|
|
| 34 |
CITIGROUP INC |
11,838 |
59,000 |
0.10% |
|
|
| 35 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
11,240 |
56,000 |
0.10% |
|
|
| 36 |
CREDIT SUISSE AG/ |
10,457 |
52,000 |
0.09% |
|
|
| 37 |
Nationwide Fund Advisors |
9,112 |
46,000 |
0.08% |
|
|
| 38 |
AMERICAN INTERNATIONAL GROUP, INC. |
8,402 |
42,000 |
0.07% |
|
|
| 39 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
6,572 |
32,000 |
0.06% |
|
|
| 40 |
BLACKROCK ADVISORS LLC |
6,405 |
32,000 |
0.06% |
|
|
| 41 |
MORGAN STANLEY |
3,631 |
19,000 |
0.03% |
|
|
| 42 |
WELLS FARGO & COMPANY/MN |
2,278 |
11,000 |
0.02% |
|
|
| 43 |
BANK OF AMERICA CORP /DE/ |
400 |
2,000 |
0.00% |
|
|
| 44 |
BlackRock Finance, Inc. |
225 |
1,000 |
0.00% |
|
|
| 45 |
Tower Research Capital LLC (TRC) |
37 |
0 |
0.00% |
|
|
