| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,046,967 | 20,981,000 | 12.78% | ||
| 2 | FRANKLIN RESOURCES INC | 1,562,800 | 16,019,000 | 9.76% | ||
| 3 | MENORA MIVTACHIM HOLDINGS LTD. | 1,133,390 | 11,617,000 | 7.08% | ||
| 4 | DSC Advisors, L.P. | 984,734 | 10,094,000 | 6.15% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 948,934 | 9,727,000 | 5.92% | ||
| 6 | Visium Asset Management, LP | 774,000 | 7,934,000 | 4.83% | ||
| 7 | SENZAR ASSET MANAGEMENT, LLC | 707,449 | 7,251,000 | 4.42% | ||
| 8 | Bank of New York Mellon Corp | 655,879 | 6,722,000 | 4.09% | ||
| 9 | BlackRock Fund Advisors | 592,874 | 6,077,000 | 3.70% | ||
| 10 | Alyeska Investment Group, L.P. | 471,098 | 4,829,000 | 2.94% | ||
| 11 | PFM Health Sciences, LP | 446,909 | 4,581,000 | 2.79% | ||
| 12 | Tekla Capital Management LLC | 413,800 | 4,241,000 | 2.58% | ||
| 13 | J. Goldman & Co LP | 405,000 | 4,151,000 | 2.53% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 380,000 | 3,895,000 | 2.37% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 377,616 | 3,871,000 | 2.36% | ||
| 16 | ACADIAN ASSET MANAGEMENT LLC | 360,785 | 3,699,000 | 2.25% | ||
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 286,299 | 2,934,000 | 1.79% | ||
| 18 | Informed Momentum Co LLC | 261,161 | 2,677,000 | 1.63% | ||
| 19 | Ghost Tree Capital, LLC | 250,000 | 2,563,000 | 1.56% | ||
| 20 | Pentwater Capital Management LP | 199,132 | 2,041,000 | 1.24% | ||
| 21 | BAILLIE GIFFORD & CO | 189,400 | 1,942,000 | 1.18% | ||
| 22 | STATE STREET CORP | 179,139 | 1,836,000 | 1.12% | ||
| 23 | SABBY MANAGEMENT, LLC | 176,000 | 1,804,000 | 1.10% | ||
| 24 | FARALLON CAPITAL MANAGEMENT LLC | 170,000 | 1,743,000 | 1.06% | ||
| 25 | BlackRock Institutional Trust Company, N.A. | 166,031 | 1,702,000 | 1.04% | ||
| 26 | Sio Capital Management, LLC | 161,286 | 1,653,000 | 1.01% | ||
| 27 | ASCEND CAPITAL, LLC | 156,000 | 1,600,000 | 0.97% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 100,800 | 1,033,000 | 0.63% | ||
| 29 | Neuberger Berman Group LLC | 90,700 | 930,000 | 0.57% | ||
| 30 | MENTA CAPITAL LLC | 86,909 | 891,000 | 0.54% | ||
| 31 | Opaleye Management Inc. | 85,000 | 871,000 | 0.53% | ||
| 32 | BlackRock Investment Management, LLC | 81,346 | 834,000 | 0.51% | ||
| 33 | RUSSELL FRANK CO/ | 69,791 | 715,000 | 0.44% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 62,680 | 642,000 | 0.39% | ||
| 35 | FEDERATED HERMES, INC. | 60,000 | 615,000 | 0.37% | ||
| 36 | PDT Partners, LLC | 59,236 | 607,000 | 0.37% | ||
| 37 | DEUTSCHE BANK AG\ | 52,009 | 532,000 | 0.32% | ||
| 38 | Lombard Odier Asset Management (USA) Corp | 51,658 | 530,000 | 0.32% | ||
| 39 | TFS CAPITAL LLC | 43,876 | 450,000 | 0.27% | ||
| 40 | D. E. Shaw & Co., Inc. | 42,039 | 431,000 | 0.26% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,312 | 423,000 | 0.26% | ||
| 42 | VANGUARD GROUP INC | 39,865 | 409,000 | 0.25% | ||
| 43 | A.R.T. Advisors, LLC | 37,339 | 382,000 | 0.23% | ||
| 44 | TUDOR INVESTMENT CORP ET AL | 36,411 | 373,000 | 0.23% | ||
| 45 | Achievement Holdings L.P. | 33,000 | 338,000 | 0.21% | ||
| 46 | TEACHERS ADVISORS, LLC | 32,854 | 337,000 | 0.21% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,336 | 332,000 | 0.20% | ||
| 48 | ACUTA CAPITAL PARTNERS, LLC | 30,000 | 308,000 | 0.19% | ||
| 49 | ALPS ADVISORS INC | 29,846 | 306,000 | 0.19% | ||
| 50 | GOLDMAN SACHS GROUP INC | 28,029 | 287,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
