| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,241,702 | 14,235,000 | 13.23% | ||
| 2 | FRANKLIN RESOURCES INC | 1,537,970 | 9,766,000 | 9.08% | ||
| 3 | DSC Advisors, L.P. | 1,498,211 | 9,514,000 | 8.84% | ||
| 4 | MENORA MIVTACHIM HOLDINGS LTD. | 1,350,847 | 8,578,000 | 7.97% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,282,058 | 8,141,000 | 7.57% | ||
| 6 | Tekla Capital Management LLC | 966,065 | 6,135,000 | 5.70% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 795,000 | 5,048,000 | 4.69% | ||
| 8 | Opaleye Management Inc. | 695,000 | 4,413,000 | 4.10% | ||
| 9 | DRIEHAUS CAPITAL MANAGEMENT LLC | 613,236 | 3,894,000 | 3.62% | ||
| 10 | SENZAR ASSET MANAGEMENT, LLC | 598,397 | 3,799,821 | 3.53% | ||
| 11 | Alyeska Investment Group, L.P. | 569,403 | 3,616,000 | 3.36% | ||
| 12 | Bank of New York Mellon Corp | 551,350 | 3,501,000 | 3.25% | ||
| 13 | J. Goldman & Co LP | 496,547 | 3,153,000 | 2.93% | ||
| 14 | Sio Capital Management, LLC | 405,374 | 2,574,000 | 2.39% | ||
| 15 | BlackRock Fund Advisors | 385,144 | 2,446,000 | 2.27% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 342,000 | 2,172,000 | 2.02% | ||
| 17 | GREAT POINT PARTNERS LLC | 274,756 | 1,745,000 | 1.62% | ||
| 18 | SABBY MANAGEMENT, LLC | 253,706 | 1,611,000 | 1.50% | ||
| 19 | FOLGER HILL ASSET MANAGEMENT LP | 237,995 | 1,511,000 | 1.40% | ||
| 20 | BAILLIE GIFFORD & CO | 219,400 | 1,393,000 | 1.30% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 197,508 | 1,254,000 | 1.17% | ||
| 22 | DAFNA Capital Management LLC | 192,567 | 1,223,000 | 1.14% | ||
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 148,377 | 942,000 | 0.88% | ||
| 24 | MENTA CAPITAL LLC | 145,508 | 924,000 | 0.86% | ||
| 25 | NEXTHERA CAPITAL LP | 145,250 | 922,000 | 0.86% | ||
| 26 | PURA VIDA INVESTMENTS, LLC | 102,000 | 648,000 | 0.60% | ||
| 27 | Paloma Partners Management Co | 92,200 | 585,000 | 0.54% | ||
| 28 | CREDIT SUISSE AG/ | 90,722 | 576,000 | 0.54% | ||
| 29 | DEUTSCHE BANK AG\ | 89,665 | 569,000 | 0.53% | ||
| 30 | Laurion Capital Management LP | 65,400 | 415,000 | 0.39% | ||
| 31 | BAIRD FINANCIAL GROUP, INC. | 58,964 | 374,000 | 0.35% | ||
| 32 | D. E. Shaw & Co., Inc. | 52,401 | 333,000 | 0.31% | ||
| 33 | GOLDMAN SACHS GROUP INC | 46,058 | 292,000 | 0.27% | ||
| 34 | TFS CAPITAL LLC | 34,930 | 222,000 | 0.21% | ||
| 35 | ProShare Advisors LLC | 22,818 | 145,000 | 0.13% | ||
| 36 | LMR Partners LLP | 17,600 | 112,000 | 0.10% | ||
| 37 | Alpine Global Management, LLC | 17,092 | 109,000 | 0.10% | ||
| 38 | MORGAN STANLEY | 15,397 | 98,000 | 0.09% | ||
| 39 | VAN ECK ASSOCIATES CORP | 14,776 | 94,000 | 0.09% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 13,929 | 88,000 | 0.08% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,448 | 85,000 | 0.08% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 12,381 | 79,000 | 0.07% | ||
| 43 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 11,236 | 71,000 | 0.07% | ||
| 44 | Tower Research Capital LLC (TRC) | 7,455 | 47,000 | 0.04% | ||
| 45 | CITIGROUP INC | 5,656 | 36,000 | 0.03% | ||
| 46 | PENSERRA CAPITAL MANAGEMENT LLC | 3,042 | 19,000 | 0.02% | ||
| 47 | BARCLAYS PLC | 2,795 | 17,000 | 0.02% | ||
| 48 | VICTORY CAPITAL MANAGEMENT INC | 1,760 | 11,000 | 0.01% | ||
| 49 | UBS Group AG | 1,477 | 9,000 | 0.01% | ||
| 50 | Financial Architects, Inc | 1,000 | 6,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
