| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 2,769,425 | 25,645,000 | 11.55% | ||
| 2 | BAKER BROS. ADVISORS LP | 2,466,702 | 22,842,000 | 10.29% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,820,138 | 16,854,000 | 7.59% | ||
| 4 | DSC Advisors, L.P. | 1,667,377 | 15,440,000 | 6.96% | ||
| 5 | FRANKLIN RESOURCES INC | 1,539,270 | 14,254,000 | 6.42% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 1,373,284 | 12,717,000 | 5.73% | ||
| 7 | MENORA MIVTACHIM HOLDINGS LTD. | 1,350,847 | 12,509,000 | 5.63% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,307,058 | 12,103,000 | 5.45% | ||
| 9 | Tekla Capital Management LLC | 966,065 | 8,946,000 | 4.03% | ||
| 10 | VIVO CAPITAL, LLC | 855,000 | 7,917,000 | 3.57% | ||
| 11 | DRIEHAUS CAPITAL MANAGEMENT LLC | 790,116 | 7,316,000 | 3.30% | ||
| 12 | AXA S.A. | 692,835 | 6,416,000 | 2.89% | ||
| 13 | Alyeska Investment Group, L.P. | 650,125 | 6,020,000 | 2.71% | ||
| 14 | Opaleye Management Inc. | 630,000 | 5,834,000 | 2.63% | ||
| 15 | Bank of New York Mellon Corp | 524,474 | 4,857,000 | 2.19% | ||
| 16 | SENZAR ASSET MANAGEMENT, LLC | 523,397 | 4,846,656 | 2.18% | ||
| 17 | FOLGER HILL ASSET MANAGEMENT LP | 512,995 | 4,750,000 | 2.14% | ||
| 18 | BlackRock Fund Advisors | 411,727 | 3,813,000 | 1.72% | ||
| 19 | J. Goldman & Co LP | 388,000 | 3,593,000 | 1.62% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 342,000 | 3,167,000 | 1.43% | ||
| 21 | DAFNA Capital Management LLC | 278,067 | 2,575,000 | 1.16% | ||
| 22 | BARCLAYS PLC | 262,536 | 2,431,000 | 1.10% | ||
| 23 | MONASHEE INVESTMENT MANAGEMENT LLC | 225,000 | 2,084,000 | 0.94% | PRN | |
| 24 | BAILLIE GIFFORD & CO | 219,400 | 2,032,000 | 0.92% | ||
| 25 | SABBY MANAGEMENT, LLC | 201,564 | 1,866,000 | 0.84% | ||
| 26 | Ghost Tree Capital, LLC | 157,962 | 1,463,000 | 0.66% | ||
| 27 | PURA VIDA INVESTMENTS, LLC | 137,000 | 1,269,000 | 0.57% | ||
| 28 | NEXTHERA CAPITAL LP | 125,000 | 1,158,000 | 0.52% | ||
| 29 | MENTA CAPITAL LLC | 123,123 | 1,140,000 | 0.51% | ||
| 30 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 122,176 | 1,132,000 | 0.51% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 75,337 | 698,000 | 0.31% | ||
| 32 | Neuberger Berman Group LLC | 65,000 | 602,000 | 0.27% | ||
| 33 | FEDERATED HERMES, INC. | 50,000 | 463,000 | 0.21% | ||
| 34 | RAYMOND JAMES & ASSOCIATES | 45,200 | 419,000 | 0.19% | ||
| 35 | JANE STREET GROUP, LLC | 30,591 | 283,000 | 0.13% | ||
| 36 | GOLDMAN SACHS GROUP INC | 28,697 | 266,000 | 0.12% | ||
| 37 | DEUTSCHE BANK AG\ | 27,269 | 252,000 | 0.11% | ||
| 38 | NORTHERN TRUST CORP | 24,091 | 223,000 | 0.10% | ||
| 39 | D. E. Shaw & Co., Inc. | 20,358 | 189,000 | 0.09% | ||
| 40 | CREDIT SUISSE AG/ | 20,287 | 188,000 | 0.08% | ||
| 41 | ProShare Advisors LLC | 19,337 | 179,000 | 0.08% | ||
| 42 | ELLINGTON MANAGEMENT GROUP LLC | 18,300 | 169,000 | 0.08% | ||
| 43 | Geduld E E | 16,843 | 156,000 | 0.07% | ||
| 44 | TUDOR INVESTMENT CORP ET AL | 15,000 | 139,000 | 0.06% | ||
| 45 | VAN ECK ASSOCIATES CORP | 14,831 | 137,000 | 0.06% | ||
| 46 | GEODE CAPITAL MANAGEMENT, LLC | 14,017 | 129,000 | 0.06% | ||
| 47 | TFS CAPITAL LLC | 11,510 | 107,000 | 0.05% | ||
| 48 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 10,218 | 95,000 | 0.04% | ||
| 49 | RAYMOND JAMES & ASSOCIATES | 36,700 | 73,000 | 0.03% | Call | |
| 50 | CITIGROUP INC | 6,000 | 56,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
