| 1 |
BAKER BROS. ADVISORS LP |
2,241,702 |
14,616,000 |
12.41% |
|
|
| 2 |
SENZAR ASSET MANAGEMENT, LLC |
1,599,031 |
10,425,682 |
8.85% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
1,539,060 |
10,035,000 |
8.52% |
|
|
| 4 |
DSC Advisors, L.P. |
1,494,399 |
9,743,000 |
8.27% |
|
|
| 5 |
MENORA MIVTACHIM HOLDINGS LTD. |
1,350,847 |
8,808,000 |
7.48% |
|
|
| 6 |
BlackRock Fund Advisors |
981,815 |
6,401,000 |
5.43% |
|
|
| 7 |
Tekla Capital Management LLC |
966,065 |
6,299,000 |
5.35% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
948,934 |
6,187,000 |
5.25% |
|
|
| 9 |
Bank of New York Mellon Corp |
618,580 |
4,033,000 |
3.42% |
|
|
| 10 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
618,107 |
4,030,000 |
3.42% |
|
|
| 11 |
Opaleye Management Inc. |
590,000 |
3,847,000 |
3.27% |
|
|
| 12 |
Sio Capital Management, LLC |
572,628 |
3,734,000 |
3.17% |
|
|
| 13 |
J. Goldman & Co LP |
569,180 |
3,711,000 |
3.15% |
|
|
| 14 |
Alyeska Investment Group, L.P. |
557,849 |
3,637,000 |
3.09% |
|
|
| 15 |
SPHERA FUNDS MANAGEMENT LTD. |
342,000 |
2,230,000 |
1.89% |
|
|
| 16 |
STATE STREET CORP |
293,003 |
1,908,000 |
1.62% |
|
|
| 17 |
SABBY MANAGEMENT, LLC |
260,400 |
1,698,000 |
1.44% |
|
|
| 18 |
FOLGER HILL ASSET MANAGEMENT LP |
237,995 |
1,552,000 |
1.32% |
|
|
| 19 |
BAILLIE GIFFORD & CO |
219,400 |
1,430,000 |
1.21% |
|
|
| 20 |
NORTHERN TRUST CORP |
205,644 |
1,341,000 |
1.14% |
|
|
| 21 |
JPMORGAN CHASE & CO |
188,925 |
1,232,000 |
1.05% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
184,921 |
1,206,000 |
1.02% |
|
|
| 23 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
148,891 |
971,000 |
0.82% |
|
|
| 24 |
DAFNA Capital Management LLC |
118,671 |
774,000 |
0.66% |
|
|
| 25 |
MILLENNIUM MANAGEMENT LLC |
114,574 |
747,000 |
0.63% |
|
|
| 26 |
MENTA CAPITAL LLC |
112,811 |
736,000 |
0.62% |
|
|
| 27 |
PURA VIDA INVESTMENTS, LLC |
102,000 |
665,000 |
0.56% |
|
|
| 28 |
BlackRock Investment Management, LLC |
84,768 |
553,000 |
0.47% |
|
|
| 29 |
BAIRD FINANCIAL GROUP, INC. |
84,134 |
549,000 |
0.47% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
76,145 |
496,000 |
0.42% |
|
|
| 31 |
VANGUARD GROUP INC |
63,069 |
412,000 |
0.35% |
|
|
| 32 |
D. E. Shaw & Co., Inc. |
60,294 |
393,000 |
0.33% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
54,079 |
351,000 |
0.30% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
48,805 |
318,000 |
0.27% |
|
|
| 35 |
GEODE CAPITAL MANAGEMENT, LLC |
38,243 |
249,000 |
0.21% |
|
|
| 36 |
ALPS ADVISORS INC |
34,363 |
224,000 |
0.19% |
|
|
| 37 |
TEACHERS ADVISORS, LLC |
32,854 |
214,000 |
0.18% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
32,336 |
211,000 |
0.18% |
|
|
| 39 |
Raymond James Financial Services Advisors, Inc. |
26,900 |
175,000 |
0.15% |
|
|
| 40 |
ProShare Advisors LLC |
25,223 |
164,000 |
0.14% |
|
|
| 41 |
CITIGROUP INC |
24,474 |
160,000 |
0.14% |
|
|
| 42 |
RHUMBLINE ADVISERS |
22,719 |
148,000 |
0.13% |
|
|
| 43 |
NEW YORK STATE COMMON RETIREMENT FUND |
20,600 |
134,000 |
0.11% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
15,335 |
100,000 |
0.08% |
|
|
| 45 |
VAN ECK ASSOCIATES CORP |
15,202 |
99,000 |
0.08% |
|
|
| 46 |
Nationwide Fund Advisors |
14,509 |
95,000 |
0.08% |
|
|
| 47 |
A.R.T. Advisors, LLC |
13,440 |
87,000 |
0.07% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
13,247 |
86,000 |
0.07% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
14,184 |
86,000 |
0.07% |
|
|
| 50 |
DekaBank Deutsche Girozentrale |
13,000 |
85,000 |
0.07% |
|
|
