| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2,046,967 | 15,004,000 | 11.54% | ||
| 2 | FRANKLIN RESOURCES INC | 1,692,200 | 12,404,000 | 9.54% | ||
| 3 | MENORA MIVTACHIM HOLDINGS LTD. | 1,350,847 | 9,902,000 | 7.61% | ||
| 4 | DSC Advisors, L.P. | 1,000,000 | 7,330,000 | 5.64% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 948,934 | 6,956,000 | 5.35% | ||
| 6 | SENZAR ASSET MANAGEMENT, LLC | 864,408 | 6,336,111 | 4.87% | ||
| 7 | Bank of New York Mellon Corp | 770,559 | 5,648,000 | 4.34% | ||
| 8 | Tekla Capital Management LLC | 613,577 | 4,498,000 | 3.46% | ||
| 9 | BlackRock Fund Advisors | 596,994 | 4,376,000 | 3.36% | ||
| 10 | DRIEHAUS CAPITAL MANAGEMENT LLC | 548,724 | 4,022,000 | 3.09% | ||
| 11 | Alyeska Investment Group, L.P. | 510,191 | 3,740,000 | 2.88% | ||
| 12 | PFM Health Sciences, LP | 506,920 | 3,716,000 | 2.86% | ||
| 13 | J. Goldman & Co LP | 474,810 | 3,480,000 | 2.68% | ||
| 14 | ALPS ADVISORS INC | 47,089 | 3,452,000 | 2.65% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 380,000 | 2,785,000 | 2.14% | ||
| 16 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 342,857 | 2,513,000 | 1.93% | ||
| 17 | Sio Capital Management, LLC | 336,286 | 2,465,000 | 1.90% | ||
| 18 | ASCEND CAPITAL, LLC | 300,000 | 2,199,000 | 1.69% | ||
| 19 | Opaleye Management Inc. | 285,000 | 2,089,000 | 1.61% | ||
| 20 | ACADIAN ASSET MANAGEMENT LLC | 283,589 | 2,079,000 | 1.60% | ||
| 21 | CADIAN CAPITAL MANAGEMENT, LP | 267,236 | 1,959,000 | 1.51% | ||
| 22 | SABBY MANAGEMENT, LLC | 243,361 | 1,784,000 | 1.37% | ||
| 23 | STATE STREET CORP | 240,527 | 1,763,000 | 1.36% | ||
| 24 | BAILLIE GIFFORD & CO | 219,400 | 1,608,000 | 1.24% | ||
| 25 | Informed Momentum Co LLC | 218,200 | 1,599,000 | 1.23% | ||
| 26 | NORTHERN TRUST CORP | 197,986 | 1,452,000 | 1.12% | ||
| 27 | BlackRock Institutional Trust Company, N.A. | 180,943 | 1,326,000 | 1.02% | ||
| 28 | FARALLON CAPITAL MANAGEMENT LLC | 170,900 | 1,253,000 | 0.96% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 158,397 | 1,161,000 | 0.89% | ||
| 30 | Ghost Tree Capital, LLC | 150,000 | 1,100,000 | 0.85% | ||
| 31 | PURA VIDA INVESTMENTS, LLC | 102,000 | 748,000 | 0.58% | ||
| 32 | MENTA CAPITAL LLC | 91,811 | 673,000 | 0.52% | ||
| 33 | BlackRock Investment Management, LLC | 82,947 | 608,000 | 0.47% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 76,145 | 558,000 | 0.43% | ||
| 35 | DEUTSCHE BANK AG\ | 71,806 | 524,000 | 0.40% | ||
| 36 | PointState Capital LP | 67,500 | 495,000 | 0.38% | ||
| 37 | Numeric Investors LLC | 66,600 | 488,000 | 0.38% | ||
| 38 | Neuberger Berman Group LLC | 62,500 | 458,000 | 0.35% | ||
| 39 | VANGUARD GROUP INC | 62,303 | 457,000 | 0.35% | ||
| 40 | FEDERATED HERMES, INC. | 60,000 | 440,000 | 0.34% | ||
| 41 | DECADE CAPITAL MANAGEMENT LLC | 60,000 | 440,000 | 0.34% | ||
| 42 | RUSSELL FRANK CO/ | 59,867 | 439,000 | 0.34% | ||
| 43 | PDT Partners, LLC | 58,052 | 426,000 | 0.33% | ||
| 44 | Lombard Odier Asset Management (USA) Corp | 51,692 | 379,000 | 0.29% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,212 | 302,000 | 0.23% | ||
| 46 | TEACHERS ADVISORS, LLC | 32,854 | 241,000 | 0.19% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,336 | 238,000 | 0.18% | ||
| 48 | GEODE CAPITAL MANAGEMENT, LLC | 32,186 | 235,000 | 0.18% | ||
| 49 | GOLDMAN SACHS GROUP INC | 24,997 | 183,000 | 0.14% | ||
| 50 | MORGAN STANLEY | 22,231 | 163,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
