| 1 |
BAKER BROS. ADVISORS LP |
2,046,967 |
16,601,000 |
11.57% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
1,675,060 |
13,585,000 |
9.47% |
|
|
| 3 |
SENZAR ASSET MANAGEMENT, LLC |
1,497,431 |
12,144,165 |
8.47% |
|
|
| 4 |
DSC Advisors, L.P. |
1,408,597 |
11,424,000 |
7.96% |
|
|
| 5 |
MENORA MIVTACHIM HOLDINGS LTD. |
1,350,847 |
10,955,000 |
7.64% |
|
|
| 6 |
BlackRock Fund Advisors |
968,305 |
7,853,000 |
5.47% |
|
|
| 7 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
948,934 |
7,696,000 |
5.36% |
|
|
| 8 |
Tekla Capital Management LLC |
652,145 |
5,289,000 |
3.69% |
|
|
| 9 |
Bank of New York Mellon Corp |
650,731 |
5,277,000 |
3.68% |
|
|
| 10 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
640,378 |
5,193,000 |
3.62% |
|
|
| 11 |
J. Goldman & Co LP |
580,000 |
4,704,000 |
3.28% |
|
|
| 12 |
Alyeska Investment Group, L.P. |
540,602 |
4,384,000 |
3.06% |
|
|
| 13 |
Opaleye Management Inc. |
500,000 |
4,055,000 |
2.83% |
|
|
| 14 |
Sio Capital Management, LLC |
415,972 |
3,374,000 |
2.35% |
|
|
| 15 |
SPHERA FUNDS MANAGEMENT LTD. |
342,000 |
2,774,000 |
1.93% |
|
|
| 16 |
STATE STREET CORP |
281,227 |
2,281,000 |
1.59% |
|
|
| 17 |
CADIAN CAPITAL MANAGEMENT, LP |
267,236 |
2,167,000 |
1.51% |
|
|
| 18 |
SABBY MANAGEMENT, LLC |
238,400 |
1,933,000 |
1.35% |
|
|
| 19 |
FOLGER HILL ASSET MANAGEMENT LP |
237,995 |
1,930,000 |
1.35% |
|
|
| 20 |
BAILLIE GIFFORD & CO |
219,400 |
1,780,000 |
1.24% |
|
|
| 21 |
JPMORGAN CHASE & CO |
206,000 |
1,671,000 |
1.16% |
|
|
| 22 |
NORTHERN TRUST CORP |
205,200 |
1,664,000 |
1.16% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
190,295 |
1,543,000 |
1.08% |
|
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
112,427 |
912,000 |
0.64% |
|
|
| 25 |
MENTA CAPITAL LLC |
109,011 |
884,000 |
0.62% |
|
|
| 26 |
PURA VIDA INVESTMENTS, LLC |
102,000 |
827,000 |
0.58% |
|
|
| 27 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
98,558 |
799,000 |
0.56% |
|
|
| 28 |
BAIRD FINANCIAL GROUP, INC. |
84,134 |
682,000 |
0.48% |
|
|
| 29 |
BlackRock Investment Management, LLC |
83,171 |
675,000 |
0.47% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
76,145 |
618,000 |
0.43% |
|
|
| 31 |
VANGUARD GROUP INC |
64,978 |
527,000 |
0.37% |
|
|
| 32 |
ACADIAN ASSET MANAGEMENT LLC |
63,926 |
518,000 |
0.36% |
|
|
| 33 |
DAFNA Capital Management LLC |
60,770 |
493,000 |
0.34% |
|
|
| 34 |
FEDERATED HERMES, INC. |
60,000 |
487,000 |
0.34% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
58,169 |
470,000 |
0.33% |
|
|
| 36 |
D. E. Shaw & Co., Inc. |
54,388 |
441,000 |
0.31% |
|
|
| 37 |
Lombard Odier Asset Management (USA) Corp |
53,847 |
437,000 |
0.30% |
|
|
| 38 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
41,961 |
340,000 |
0.24% |
|
|
| 39 |
ASCEND CAPITAL, LLC |
41,611 |
337,000 |
0.23% |
|
|
| 40 |
ALPS ADVISORS INC |
40,253 |
326,000 |
0.23% |
|
|
| 41 |
Quantitative Systematic Strategies LLC |
36,788 |
302,000 |
0.21% |
|
|
| 42 |
GEODE CAPITAL MANAGEMENT, LLC |
33,669 |
273,000 |
0.19% |
|
|
| 43 |
TEACHERS ADVISORS, LLC |
32,854 |
266,000 |
0.19% |
|
|
| 44 |
WELLS FARGO & COMPANY/MN |
32,430 |
263,000 |
0.18% |
|
|
| 45 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
32,336 |
263,000 |
0.18% |
|
|
| 46 |
A.R.T. Advisors, LLC |
31,140 |
252,000 |
0.18% |
|
|
| 47 |
ProShare Advisors LLC |
27,868 |
226,000 |
0.16% |
|
|
| 48 |
RHUMBLINE ADVISERS |
22,719 |
184,000 |
0.13% |
|
|
| 49 |
MORGAN STANLEY |
21,856 |
177,000 |
0.12% |
|
|
| 50 |
NEW YORK STATE COMMON RETIREMENT FUND |
20,600 |
167,000 |
0.12% |
|
|
