| # | % | |||||
|---|---|---|---|---|---|---|
| 51 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 182,800 | 905,000 | 0.75% | Call | |
| 52 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 197,838 | 979,000 | 0.82% | ||
| 53 | EMORY UNIVERSITY | 203,519 | 1,007,000 | 0.84% | ||
| 54 | BAILLIE GIFFORD & CO | 219,400 | 1,086,000 | 0.91% | ||
| 55 | SPHERA FUNDS MANAGEMENT LTD. | 242,000 | 1,198,000 | 1.00% | ||
| 56 | MILLENNIUM MANAGEMENT LLC | 253,384 | 1,254,000 | 1.05% | ||
| 57 | DAFNA Capital Management LLC | 325,667 | 1,612,000 | 1.34% | ||
| 58 | JENNISON ASSOCIATES LLC | 340,289 | 1,684,000 | 1.40% | ||
| 59 | Bank of New York Mellon Corp | 393,004 | 1,945,000 | 1.62% | ||
| 60 | DRIEHAUS CAPITAL MANAGEMENT LLC | 432,398 | 2,140,000 | 1.78% | ||
| 61 | MARSHALL WACE ASIA LTD | 443,469 | 2,217,000 | 1.85% | ||
| 62 | MARSHALL WACE NORTH AMERICA, L.P. | 443,469 | 2,217,000 | 1.85% | ||
| 63 | FOLGER HILL ASSET MANAGEMENT LP | 451,869 | 2,237,000 | 1.87% | ||
| 64 | Opaleye Management Inc. | 500,000 | 2,475,000 | 2.06% | ||
| 65 | Alyeska Investment Group, L.P. | 502,579 | 2,488,000 | 2.07% | ||
| 66 | BlackRock Finance, Inc. | 516,145 | 2,555,000 | 2.13% | ||
| 67 | DLD ASSET MANAGEMENT, LP | 523,900 | 2,598,000 | 2.17% | Call | |
| 68 | OppenheimerFunds, Inc. | 548,529 | 2,715,000 | 2.26% | ||
| 69 | SENZAR ASSET MANAGEMENT, LLC | 574,797 | 2,845,000 | 2.37% | ||
| 70 | DEERFIELD MANAGEMENT COMPANY, L.P. | 817,435 | 4,046,000 | 3.37% | ||
| 71 | AXA S.A. | 826,437 | 4,091,000 | 3.41% | ||
| 72 | VIVO CAPITAL, LLC | 855,000 | 4,232,000 | 3.53% | ||
| 73 | Tekla Capital Management LLC | 930,398 | 4,605,000 | 3.84% | ||
| 74 | DSC Advisors, L.P. | 1,186,654 | 5,874,000 | 4.90% | ||
| 75 | PERCEPTIVE ADVISORS LLC | 1,322,994 | 6,549,000 | 5.46% | ||
| 76 | FRANKLIN RESOURCES INC | 1,498,870 | 7,420,000 | 6.19% | ||
| 77 | RA CAPITAL MANAGEMENT, L.P. | 1,820,138 | 9,010,000 | 7.51% | ||
| 78 | BAKER BROS. ADVISORS LP | 2,466,702 | 12,210,000 | 10.18% | ||
| 79 | GREAT POINT PARTNERS LLC | 3,681,708 | 18,224,000 | 15.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
