| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 3,681,708 | 18,224,000 | 15.19% | ||
| 2 | BAKER BROS. ADVISORS LP | 2,466,702 | 12,210,000 | 10.18% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,820,138 | 9,010,000 | 7.51% | ||
| 4 | FRANKLIN RESOURCES INC | 1,498,870 | 7,420,000 | 6.19% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 1,322,994 | 6,549,000 | 5.46% | ||
| 6 | DSC Advisors, L.P. | 1,186,654 | 5,874,000 | 4.90% | ||
| 7 | Tekla Capital Management LLC | 930,398 | 4,605,000 | 3.84% | ||
| 8 | VIVO CAPITAL, LLC | 855,000 | 4,232,000 | 3.53% | ||
| 9 | AXA S.A. | 826,437 | 4,091,000 | 3.41% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 817,435 | 4,046,000 | 3.37% | ||
| 11 | SENZAR ASSET MANAGEMENT, LLC | 574,797 | 2,845,000 | 2.37% | ||
| 12 | OppenheimerFunds, Inc. | 548,529 | 2,715,000 | 2.26% | ||
| 13 | DLD ASSET MANAGEMENT, LP | 523,900 | 2,598,000 | 2.17% | Call | |
| 14 | BlackRock Finance, Inc. | 516,145 | 2,555,000 | 2.13% | ||
| 15 | Alyeska Investment Group, L.P. | 502,579 | 2,488,000 | 2.07% | ||
| 16 | Opaleye Management Inc. | 500,000 | 2,475,000 | 2.06% | ||
| 17 | FOLGER HILL ASSET MANAGEMENT LP | 451,869 | 2,237,000 | 1.87% | ||
| 18 | MARSHALL WACE ASIA LTD | 443,469 | 2,217,000 | 1.85% | ||
| 19 | MARSHALL WACE NORTH AMERICA, L.P. | 443,469 | 2,217,000 | 1.85% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 432,398 | 2,140,000 | 1.78% | ||
| 21 | Bank of New York Mellon Corp | 393,004 | 1,945,000 | 1.62% | ||
| 22 | JENNISON ASSOCIATES LLC | 340,289 | 1,684,000 | 1.40% | ||
| 23 | DAFNA Capital Management LLC | 325,667 | 1,612,000 | 1.34% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 253,384 | 1,254,000 | 1.05% | ||
| 25 | SPHERA FUNDS MANAGEMENT LTD. | 242,000 | 1,198,000 | 1.00% | ||
| 26 | BAILLIE GIFFORD & CO | 219,400 | 1,086,000 | 0.91% | ||
| 27 | EMORY UNIVERSITY | 203,519 | 1,007,000 | 0.84% | ||
| 28 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 197,838 | 979,000 | 0.82% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 182,800 | 905,000 | 0.75% | Call | |
| 30 | Crestline Management, LP | 101,700 | 819,000 | 0.68% | ||
| 31 | GOLDMAN SACHS GROUP INC | 148,981 | 737,000 | 0.61% | ||
| 32 | Ghost Tree Capital, LLC | 125,000 | 619,000 | 0.52% | ||
| 33 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 104,679 | 518,161 | 0.43% | ||
| 34 | MENORA MIVTACHIM HOLDINGS LTD. | 103,290 | 511,000 | 0.43% | ||
| 35 | DLD ASSET MANAGEMENT, LP | 77,800 | 385,000 | 0.32% | ||
| 36 | DLD ASSET MANAGEMENT, LP | 68,700 | 341,000 | 0.28% | Put | |
| 37 | D. E. Shaw & Co., Inc. | 66,373 | 329,000 | 0.27% | ||
| 38 | RENAISSANCE TECHNOLOGIES LLC | 62,014 | 307,000 | 0.26% | ||
| 39 | MENTA CAPITAL LLC | 56,378 | 279,000 | 0.23% | ||
| 40 | DEUTSCHE BANK AG\ | 47,898 | 236,000 | 0.20% | ||
| 41 | RAYMOND JAMES & ASSOCIATES | 42,000 | 208,000 | 0.17% | ||
| 42 | BAIRD FINANCIAL GROUP, INC. | 37,988 | 188,000 | 0.16% | ||
| 43 | SABBY MANAGEMENT, LLC | 35,037 | 173,000 | 0.14% | ||
| 44 | ALPS ADVISORS INC | 31,976 | 155,000 | 0.13% | ||
| 45 | CITADEL ADVISORS LLC | 31,100 | 154,000 | 0.13% | Put | |
| 46 | CITADEL ADVISORS LLC | 30,700 | 152,000 | 0.13% | Call | |
| 47 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 30,000 | 148,000 | 0.12% | ||
| 48 | CITADEL ADVISORS LLC | 29,506 | 146,000 | 0.12% | ||
| 49 | BOOTHBAY FUND MANAGEMENT, LLC | 29,000 | 144,000 | 0.12% | ||
| 50 | ELLINGTON MANAGEMENT GROUP LLC | 24,700 | 122,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
