| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 950,000 | 16,331,000 | 12.57% | ||
| 2 | Redmile Group, LLC | 765,232 | 12,067,000 | 9.29% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 698,838 | 12,013,000 | 9.25% | ||
| 4 | JENNISON ASSOCIATES LLC | 630,370 | 10,836,000 | 8.34% | ||
| 5 | BVF INC/IL | 549,000 | 9,437,000 | 7.27% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 530,000 | 9,111,000 | 7.01% | ||
| 7 | BAKER BROS. ADVISORS LP | 400,000 | 6,876,000 | 5.29% | ||
| 8 | Clearbridge Investments, LLC | 397,786 | 6,838,000 | 5.26% | ||
| 9 | SABBY MANAGEMENT, LLC | 381,249 | 6,554,000 | 5.05% | ||
| 10 | FRANKLIN RESOURCES INC | 275,000 | 4,727,000 | 3.64% | ||
| 11 | HIGHLAND CAPITAL MANAGEMENT LP | 239,331 | 4,114,000 | 3.17% | ||
| 12 | FEDERATED HERMES, INC. | 202,500 | 3,481,000 | 2.68% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 3,438,000 | 2.65% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 152,001 | 2,613,000 | 2.01% | ||
| 15 | LORD, ABBETT & CO. LLC | 151,844 | 2,610,000 | 2.01% | ||
| 16 | Visium Asset Management, LP | 137,016 | 2,355,000 | 1.81% | ||
| 17 | Alyeska Investment Group, L.P. | 135,230 | 2,325,000 | 1.79% | ||
| 18 | MARSHALL WACE, LLP | 113,676 | 1,954,000 | 1.50% | ||
| 19 | CITADEL ADVISORS LLC | 108,715 | 1,869,000 | 1.44% | ||
| 20 | Asset Management One Co., Ltd. | 111,613 | 1,772,000 | 1.36% | ||
| 21 | Lombard Odier Asset Management (USA) Corp | 100,000 | 1,719,000 | 1.32% | ||
| 22 | PERCEPTIVE ADVISORS LLC | 100,000 | 1,719,000 | 1.32% | ||
| 23 | FMR LLC | 72,600 | 1,248,000 | 0.96% | ||
| 24 | SECTORAL ASSET MANAGEMENT INC | 70,000 | 1,203,000 | 0.93% | ||
| 25 | BLACKROCK ADVISORS LLC | 60,800 | 1,045,000 | 0.80% | ||
| 26 | Weiss Multi-Strategy Advisers LLC | 32,160 | 553,000 | 0.43% | ||
| 27 | DEUTSCHE BANK AG\ | 24,148 | 415,000 | 0.32% | ||
| 28 | Sterling Capital Management LLC | 19,380 | 333,000 | 0.26% | ||
| 29 | MORGAN STANLEY | 15,845 | 272,000 | 0.21% | ||
| 30 | CLEARBRIDGE, LLC | 3,400 | 58,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
