| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,259,801 | 32,925,000 | 20.29% | ||
| 2 | ORBIMED ADVISORS LLC | 1,841,400 | 26,829,000 | 16.54% | ||
| 3 | BAKER BROS. ADVISORS LP | 988,299 | 14,400,000 | 8.88% | ||
| 4 | JENNISON ASSOCIATES LLC | 968,755 | 14,115,000 | 8.70% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 801,493 | 11,678,000 | 7.20% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 771,812 | 11,245,000 | 6.93% | ||
| 7 | Redmile Group, LLC | 660,816 | 9,628,000 | 5.93% | ||
| 8 | VIKING GLOBAL INVESTORS LP | 576,632 | 8,402,000 | 5.18% | ||
| 9 | Clearbridge Investments, LLC | 498,559 | 7,264,000 | 4.48% | ||
| 10 | HIGHLAND CAPITAL MANAGEMENT LP | 395,057 | 5,756,000 | 3.55% | ||
| 11 | FRANKLIN RESOURCES INC | 309,700 | 4,512,000 | 2.78% | ||
| 12 | CLOUGH CAPITAL PARTNERS L P | 216,200 | 3,150,000 | 1.94% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 209,398 | 3,051,000 | 1.88% | ||
| 14 | Century Capital Management, LLC | 129,408 | 1,885,000 | 1.16% | ||
| 15 | ALTRINSIC GLOBAL ADVISORS LLC | 105,000 | 1,530,000 | 0.94% | ||
| 16 | PRINCIPAL FINANCIAL GROUP INC | 83,250 | 1,213,000 | 0.75% | ||
| 17 | MARSHALL WACE, LLP | 64,886 | 945,000 | 0.58% | ||
| 18 | Asset Management One Co., Ltd. | 57,675 | 807,000 | 0.50% | ||
| 19 | Polar Capital LLP | 35,000 | 510,000 | 0.31% | ||
| 20 | MORGAN STANLEY | 33,516 | 488,000 | 0.30% | ||
| 21 | D. E. Shaw & Co., Inc. | 30,921 | 451,000 | 0.28% | ||
| 22 | SABBY MANAGEMENT, LLC | 21,950 | 320,000 | 0.20% | ||
| 23 | CLEARBRIDGE, LLC | 18,100 | 264,000 | 0.16% | ||
| 24 | A.R.T. Advisors, LLC | 14,361 | 209,000 | 0.13% | ||
| 25 | CITADEL ADVISORS LLC | 13,636 | 198,000 | 0.12% | ||
| 26 | GOLDMAN SACHS GROUP INC | 11,135 | 162,000 | 0.10% | ||
| 27 | Sterling Capital Management LLC | 10,911 | 159,000 | 0.10% | ||
| 28 | WELLS FARGO & COMPANY/MN | 2,500 | 36,000 | 0.02% | ||
| 29 | Walleye Trading LLC | 1,900 | 28,000 | 0.02% | ||
| 30 | DEUTSCHE BANK AG\ | 1,900 | 27,000 | 0.02% | ||
| 31 | UBS Group AG | 1,203 | 18,000 | 0.01% | ||
| 32 | Tower Research Capital LLC (TRC) | 902 | 13,000 | 0.01% | ||
| 33 | HOWARD HUGHES MEDICAL INSTITUTE | 807 | 12,000 | 0.01% | ||
| 34 | ROYAL BANK OF CANADA | 523 | 8,000 | 0.00% | ||
| 35 | Creative Planning | 400 | 6,000 | 0.00% | ||
| 36 | HOWE & RUSLING INC | 27 | 0 | 0.00% | ||
| 37 | CITIGROUP INC | 4 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
