| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 2,616,967 | 17,455,000 | 30.11% | ||
| 2 | ORBIMED ADVISORS LLC | 2,305,446 | 15,377,000 | 26.52% | ||
| 3 | BAKER BROS. ADVISORS LP | 860,464 | 5,739,000 | 9.90% | ||
| 4 | Redmile Group, LLC | 575,863 | 3,841,000 | 6.62% | ||
| 5 | Clearbridge Investments, LLC | 498,934 | 3,328,000 | 5.74% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 402,096 | 2,682,000 | 4.63% | ||
| 7 | FRANKLIN RESOURCES INC | 309,700 | 2,066,000 | 3.56% | ||
| 8 | HIGHLAND CAPITAL MANAGEMENT LP | 256,596 | 1,712,000 | 2.95% | ||
| 9 | FMR LLC | 237,916 | 1,587,000 | 2.74% | ||
| 10 | ALTRINSIC GLOBAL ADVISORS LLC | 210,556 | 1,404,000 | 2.42% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 149,268 | 996,000 | 1.72% | ||
| 12 | PRINCIPAL FINANCIAL GROUP INC | 76,494 | 510,000 | 0.88% | ||
| 13 | SABBY MANAGEMENT, LLC | 58,910 | 393,000 | 0.68% | ||
| 14 | Asset Management One Co., Ltd. | 37,786 | 255,000 | 0.44% | ||
| 15 | MORGAN STANLEY | 33,800 | 226,000 | 0.39% | ||
| 16 | M&T BANK CORP | 12,416 | 83,000 | 0.14% | ||
| 17 | JPMORGAN CHASE & CO | 12,038 | 80,000 | 0.14% | ||
| 18 | CLEARBRIDGE, LLC | 11,100 | 74,000 | 0.13% | ||
| 19 | WELLS FARGO & COMPANY/MN | 11,006 | 73,000 | 0.13% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 10,998 | 73,000 | 0.13% | ||
| 21 | DEUTSCHE BANK AG\ | 1,447 | 9,000 | 0.02% | ||
| 22 | CRIBSTONE CAPITAL MANAGEMENT, LLC | 1,000 | 6,000 | 0.01% | ||
| 23 | Tower Research Capital LLC (TRC) | 785 | 5,000 | 0.01% | ||
| 24 | Creative Planning | 400 | 3,000 | 0.01% | ||
| 25 | ROYAL BANK OF CANADA | 523 | 3,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
