| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,259,801 | 37,671,000 | 20.86% | ||
| 2 | ORBIMED ADVISORS LLC | 1,831,400 | 30,529,000 | 16.90% | ||
| 3 | BAKER BROS. ADVISORS LP | 988,299 | 16,475,000 | 9.12% | ||
| 4 | JENNISON ASSOCIATES LLC | 966,433 | 16,110,000 | 8.92% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 915,576 | 15,263,000 | 8.45% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 748,533 | 12,478,000 | 6.91% | ||
| 7 | VIKING GLOBAL INVESTORS LP | 595,307 | 9,924,000 | 5.50% | ||
| 8 | Redmile Group, LLC | 516,690 | 8,613,000 | 4.77% | ||
| 9 | Clearbridge Investments, LLC | 498,066 | 8,303,000 | 4.60% | ||
| 10 | FRANKLIN RESOURCES INC | 275,000 | 4,584,000 | 2.54% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 209,398 | 3,491,000 | 1.93% | ||
| 12 | HIGHLAND CAPITAL MANAGEMENT LP | 172,341 | 2,873,000 | 1.59% | ||
| 13 | EverPoint Asset Management, LLC | 128,235 | 2,138,000 | 1.18% | ||
| 14 | ALTRINSIC GLOBAL ADVISORS LLC | 97,890 | 1,632,000 | 0.90% | ||
| 15 | Asset Management One Co., Ltd. | 92,177 | 1,501,000 | 0.83% | ||
| 16 | SABBY MANAGEMENT, LLC | 83,000 | 1,384,000 | 0.77% | ||
| 17 | PRINCIPAL FINANCIAL GROUP INC | 81,640 | 1,361,000 | 0.75% | ||
| 18 | Century Capital Management, LLC | 75,602 | 1,260,000 | 0.70% | ||
| 19 | MARSHALL WACE, LLP | 64,886 | 1,082,000 | 0.60% | ||
| 20 | ASCEND CAPITAL, LLC | 52,235 | 869,000 | 0.48% | ||
| 21 | D. E. Shaw & Co., Inc. | 38,993 | 650,000 | 0.36% | ||
| 22 | MORGAN STANLEY | 37,471 | 625,000 | 0.35% | ||
| 23 | DEUTSCHE BANK AG\ | 25,141 | 418,000 | 0.23% | ||
| 24 | ACADIAN ASSET MANAGEMENT LLC | 18,152 | 303,000 | 0.17% | ||
| 25 | CLEARBRIDGE, LLC | 18,100 | 302,000 | 0.17% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 14,697 | 245,000 | 0.14% | ||
| 27 | CITADEL ADVISORS LLC | 13,002 | 217,000 | 0.12% | ||
| 28 | GOLDMAN SACHS GROUP INC | 11,273 | 188,000 | 0.10% | ||
| 29 | SOUND ENERGY PARTNERS, INC. | 2,000 | 33,000 | 0.02% | ||
| 30 | WELLS FARGO & COMPANY/MN | 1,500 | 25,000 | 0.01% | ||
| 31 | Cubist Systematic Strategies, LLC | 936 | 16,000 | 0.01% | ||
| 32 | HOWARD HUGHES MEDICAL INSTITUTE | 596 | 10,000 | 0.01% | ||
| 33 | ROYAL BANK OF CANADA | 523 | 9,000 | 0.00% | ||
| 34 | Tower Research Capital LLC (TRC) | 478 | 8,000 | 0.00% | ||
| 35 | UBS Group AG | 300 | 5,000 | 0.00% | ||
| 36 | Point72 Asset Management, L.P. | 100 | 2,000 | 0.00% | ||
| 37 | HOWE & RUSLING INC | 27 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
