| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 2,271,500 | 19,717,000 | 20.31% | ||
| 2 | FMR LLC | 2,259,801 | 19,615,000 | 20.21% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,001,774 | 8,695,000 | 8.96% | ||
| 4 | BAKER BROS. ADVISORS LP | 988,299 | 8,578,000 | 8.84% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 874,744 | 7,593,000 | 7.82% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 769,337 | 6,678,000 | 6.88% | ||
| 7 | VIKING GLOBAL INVESTORS LP | 581,668 | 5,049,000 | 5.20% | ||
| 8 | Redmile Group, LLC | 557,193 | 4,836,000 | 4.98% | ||
| 9 | Clearbridge Investments, LLC | 499,016 | 4,331,000 | 4.46% | ||
| 10 | HIGHLAND CAPITAL MANAGEMENT LP | 347,457 | 3,016,000 | 3.11% | ||
| 11 | FRANKLIN RESOURCES INC | 309,700 | 2,688,000 | 2.77% | ||
| 12 | ALTRINSIC GLOBAL ADVISORS LLC | 205,000 | 1,779,000 | 1.83% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 1,302,000 | 1.34% | ||
| 14 | PRINCIPAL FINANCIAL GROUP INC | 78,294 | 680,000 | 0.70% | ||
| 15 | Asset Management One Co., Ltd. | 55,573 | 422,000 | 0.43% | ||
| 16 | SABBY MANAGEMENT, LLC | 39,871 | 346,000 | 0.36% | ||
| 17 | Polar Capital LLP | 30,000 | 260,000 | 0.27% | ||
| 18 | A.R.T. Advisors, LLC | 28,202 | 244,000 | 0.25% | ||
| 19 | D. E. Shaw & Co., Inc. | 25,376 | 220,000 | 0.23% | ||
| 20 | Spark Investment Management LLC | 21,900 | 190,000 | 0.20% | ||
| 21 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 21,500 | 187,000 | 0.19% | ||
| 22 | CLEARBRIDGE, LLC | 18,100 | 157,000 | 0.16% | ||
| 23 | DEUTSCHE BANK AG\ | 15,336 | 132,000 | 0.14% | ||
| 24 | CITADEL ADVISORS LLC | 11,960 | 103,000 | 0.11% | ||
| 25 | M&T BANK CORP | 11,300 | 98,000 | 0.10% | ||
| 26 | Sterling Capital Management LLC | 10,611 | 92,000 | 0.09% | ||
| 27 | WELLS FARGO & COMPANY/MN | 3,455 | 30,000 | 0.03% | ||
| 28 | UBS Group AG | 957 | 8,000 | 0.01% | ||
| 29 | HOWARD HUGHES MEDICAL INSTITUTE | 765 | 7,000 | 0.01% | ||
| 30 | ROYAL BANK OF CANADA | 523 | 5,000 | 0.01% | ||
| 31 | Creative Planning | 400 | 3,000 | 0.00% | ||
| 32 | Tower Research Capital LLC (TRC) | 111 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
