| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,221,315 | 48,602,000 | 20.14% | ||
| 2 | ORBIMED ADVISORS LLC | 1,831,400 | 40,071,000 | 16.60% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 1,113,568 | 24,365,000 | 10.10% | ||
| 4 | JENNISON ASSOCIATES LLC | 963,465 | 21,081,000 | 8.73% | ||
| 5 | Redmile Group, LLC | 751,171 | 16,436,000 | 6.81% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 733,182 | 16,042,000 | 6.65% | ||
| 7 | Clearbridge Investments, LLC | 499,187 | 10,922,000 | 4.53% | ||
| 8 | VIKING GLOBAL INVESTORS LP | 408,408 | 8,936,000 | 3.70% | ||
| 9 | BAKER BROS. ADVISORS LP | 400,000 | 8,752,000 | 3.63% | ||
| 10 | Visium Asset Management, LP | 275,000 | 6,017,000 | 2.49% | ||
| 11 | FRANKLIN RESOURCES INC | 275,000 | 6,017,000 | 2.49% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 209,398 | 4,582,000 | 1.90% | ||
| 13 | EverPoint Asset Management, LLC | 200,000 | 4,376,000 | 1.81% | ||
| 14 | HIGHLAND CAPITAL MANAGEMENT LP | 183,500 | 4,015,000 | 1.66% | ||
| 15 | Asset Management One Co., Ltd. | 143,065 | 3,483,000 | 1.44% | ||
| 16 | LORD, ABBETT & CO. LLC | 134,858 | 2,951,000 | 1.22% | ||
| 17 | SABBY MANAGEMENT, LLC | 124,380 | 2,721,000 | 1.13% | ||
| 18 | PRINCIPAL FINANCIAL GROUP INC | 75,800 | 1,659,000 | 0.69% | ||
| 19 | Lombard Odier Asset Management (USA) Corp | 69,067 | 1,511,000 | 0.63% | ||
| 20 | Century Capital Management, LLC | 67,679 | 1,481,000 | 0.61% | ||
| 21 | MARSHALL WACE, LLP | 64,886 | 1,420,000 | 0.59% | ||
| 22 | ALTRINSIC GLOBAL ADVISORS LLC | 53,436 | 1,169,000 | 0.48% | ||
| 23 | MORGAN STANLEY | 46,370 | 1,015,000 | 0.42% | ||
| 24 | ASCEND CAPITAL, LLC | 30,000 | 656,000 | 0.27% | ||
| 25 | DEUTSCHE BANK AG\ | 23,058 | 504,000 | 0.21% | ||
| 26 | GOLDMAN SACHS GROUP INC | 19,049 | 417,000 | 0.17% | ||
| 27 | CLEARBRIDGE, LLC | 17,400 | 381,000 | 0.16% | ||
| 28 | Polar Capital LLP | 16,447 | 360,000 | 0.15% | ||
| 29 | D. E. Shaw & Co., Inc. | 15,806 | 346,000 | 0.14% | ||
| 30 | Cubist Systematic Strategies, LLC | 13,064 | 286,000 | 0.12% | ||
| 31 | Sterling Capital Management LLC | 12,000 | 280,000 | 0.12% | ||
| 32 | CITADEL ADVISORS LLC | 9,597 | 210,000 | 0.09% | ||
| 33 | A.R.T. Advisors, LLC | 9,404 | 205,000 | 0.08% | ||
| 34 | Point72 Asset Management, L.P. | 2,500 | 55,000 | 0.02% | ||
| 35 | UBS Group AG | 527 | 12,000 | 0.00% | ||
| 36 | ROYAL BANK OF CANADA | 524 | 11,000 | 0.00% | ||
| 37 | Tower Research Capital LLC (TRC) | 214 | 5,000 | 0.00% | ||
| 38 | HANSEATIC MANAGEMENT SERVICES INC | 31 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
