| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 1,829,400 | 39,643,000 | 22.92% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 746,525 | 16,177,000 | 9.35% | ||
| 3 | Redmile Group, LLC | 751,171 | 15,729,000 | 9.10% | ||
| 4 | JENNISON ASSOCIATES LLC | 569,958 | 12,351,000 | 7.14% | ||
| 5 | Clearbridge Investments, LLC | 499,403 | 10,822,000 | 6.26% | ||
| 6 | BAKER BROS. ADVISORS LP | 400,000 | 8,668,000 | 5.01% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 380,000 | 8,235,000 | 4.76% | ||
| 8 | FRANKLIN RESOURCES INC | 275,000 | 5,959,000 | 3.45% | ||
| 9 | SABBY MANAGEMENT, LLC | 253,083 | 5,484,000 | 3.17% | ||
| 10 | Visium Asset Management, LP | 250,000 | 5,418,000 | 3.13% | ||
| 11 | HIGHLAND CAPITAL MANAGEMENT LP | 209,824 | 4,547,000 | 2.63% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 209,776 | 4,546,000 | 2.63% | ||
| 13 | PointState Capital LP | 173,500 | 3,760,000 | 2.17% | ||
| 14 | Foresite Capital Management II, LLC | 173,067 | 3,750,000 | 2.17% | ||
| 15 | LORD, ABBETT & CO. LLC | 152,924 | 3,314,000 | 1.92% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 130,000 | 2,817,000 | 1.63% | ||
| 17 | Asset Management One Co., Ltd. | 129,443 | 2,537,000 | 1.47% | ||
| 18 | Lombard Odier Asset Management (USA) Corp | 103,105 | 2,234,000 | 1.29% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 100,000 | 2,167,000 | 1.25% | ||
| 20 | ASCEND CAPITAL, LLC | 90,000 | 1,950,000 | 1.13% | ||
| 21 | Weiss Multi-Strategy Advisers LLC | 79,300 | 1,718,000 | 0.99% | ||
| 22 | PRINCIPAL FINANCIAL GROUP INC | 75,400 | 1,634,000 | 0.94% | ||
| 23 | FMR LLC | 72,600 | 1,573,000 | 0.91% | ||
| 24 | Century Capital Management, LLC | 69,063 | 1,497,000 | 0.87% | ||
| 25 | Alyeska Investment Group, L.P. | 61,115 | 1,324,000 | 0.77% | ||
| 26 | BLACKROCK ADVISORS LLC | 60,600 | 1,313,000 | 0.76% | ||
| 27 | MARSHALL WACE, LLP | 58,417 | 1,266,000 | 0.73% | ||
| 28 | MORGAN STANLEY | 41,571 | 901,000 | 0.52% | ||
| 29 | Polar Capital LLP | 18,754 | 406,000 | 0.23% | ||
| 30 | CLEARBRIDGE, LLC | 17,400 | 377,000 | 0.22% | ||
| 31 | Sterling Capital Management LLC | 14,672 | 318,000 | 0.18% | ||
| 32 | DEUTSCHE BANK AG\ | 11,318 | 245,000 | 0.14% | ||
| 33 | GOLDMAN SACHS GROUP INC | 11,270 | 244,000 | 0.14% | ||
| 34 | UBS Group AG | 442 | 10,000 | 0.01% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 100 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
