| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ProQuest Associates IV LLC | 1,962,720 | 25,515,000 | 19.54% | ||
| 2 | FMR LLC | 1,462,784 | 19,016,000 | 14.56% | ||
| 3 | RS INVESTMENT MANAGEMENT CO LLC | 1,189,472 | 15,463,000 | 11.84% | ||
| 4 | SECTORAL ASSET MANAGEMENT INC | 856,867 | 11,139,000 | 8.53% | ||
| 5 | FRANKLIN RESOURCES INC | 812,226 | 10,559,000 | 8.09% | ||
| 6 | BlackRock Fund Advisors | 557,427 | 7,247,000 | 5.55% | ||
| 7 | VANGUARD GROUP INC | 326,992 | 4,251,000 | 3.26% | ||
| 8 | PUTNAM INVESTMENTS LLC | 283,656 | 3,687,000 | 2.82% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 230,886 | 3,002,000 | 2.30% | ||
| 10 | Cormorant Asset Management, LP | 189,000 | 2,457,000 | 1.88% | ||
| 11 | EVENTIDE ASSET MANAGEMENT, LLC | 180,000 | 2,340,000 | 1.79% | ||
| 12 | STATE STREET CORP | 168,119 | 2,190,000 | 1.68% | ||
| 13 | JENNISON ASSOCIATES LLC | 168,004 | 2,184,000 | 1.67% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 153,000 | 1,989,000 | 1.52% | ||
| 15 | BAKER BROS. ADVISORS LP | 148,937 | 1,936,000 | 1.48% | ||
| 16 | JPMORGAN CHASE & CO | 142,925 | 1,858,000 | 1.42% | ||
| 17 | NORTHERN TRUST CORP | 137,053 | 1,781,000 | 1.36% | ||
| 18 | PANAGORA ASSET MANAGEMENT INC | 89,454 | 1,163,000 | 0.89% | ||
| 19 | NEXTHERA CAPITAL LP | 85,138 | 1,107,000 | 0.85% | ||
| 20 | MARSHALL WACE, LLP | 76,145 | 990,000 | 0.76% | ||
| 21 | OXFORD ASSET MANAGEMENT LLP | 73,054 | 950,000 | 0.73% | ||
| 22 | Point72 Asset Management, L.P. | 70,572 | 917,000 | 0.70% | ||
| 23 | PICTET ASSET MANAGEMENT LTD | 86,100 | 862,000 | 0.66% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 61,384 | 797,000 | 0.61% | ||
| 25 | BLACKROCK ADVISORS LLC | 60,355 | 785,000 | 0.60% | ||
| 26 | Bank of New York Mellon Corp | 54,090 | 704,000 | 0.54% | ||
| 27 | TFS CAPITAL LLC | 52,818 | 687,000 | 0.53% | ||
| 28 | DEUTSCHE BANK AG\ | 45,635 | 592,000 | 0.45% | ||
| 29 | BlackRock Investment Management, LLC | 39,511 | 514,000 | 0.39% | ||
| 30 | Spark Investment Management LLC | 36,900 | 479,000 | 0.37% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 36,711 | 477,000 | 0.37% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,274 | 316,000 | 0.24% | ||
| 33 | ALPS ADVISORS INC | 22,653 | 294,000 | 0.23% | ||
| 34 | TEACHERS ADVISORS, LLC | 19,304 | 251,000 | 0.19% | ||
| 35 | Focused Wealth Management, Inc | 16,593 | 216,000 | 0.17% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,243 | 212,000 | 0.16% | ||
| 37 | ProShare Advisors LLC | 16,187 | 210,000 | 0.16% | ||
| 38 | Nationwide Fund Advisors | 10,578 | 138,000 | 0.11% | ||
| 39 | Swiss National Bank | 10,900 | 136,000 | 0.10% | ||
| 40 | RHUMBLINE ADVISERS | 10,416 | 135,000 | 0.10% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 10,300 | 134,000 | 0.10% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,100 | 131,000 | 0.10% | Call | |
| 43 | CANADA LIFE ASSURANCE Co | 9,836 | 128,000 | 0.10% | ||
| 44 | CITIGROUP INC | 7,944 | 103,000 | 0.08% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,460 | 100,000 | 0.08% | ||
| 46 | DekaBank Deutsche Girozentrale | 8,500 | 100,000 | 0.08% | ||
| 47 | AMERICAN INTERNATIONAL GROUP, INC. | 6,628 | 86,000 | 0.07% | ||
| 48 | Vident Investment Advisory, LLC | 956,904 | 74,000 | 0.06% | ||
| 49 | WELLS FARGO & COMPANY/MN | 5,312 | 69,000 | 0.05% | ||
| 50 | BlackRock Group LTD | 2,713 | 36,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
