| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Versant Venture Management, LLC | 2,208,210 | 12,145,155 | 16.76% | ||
| 2 | ProQuest Associates IV LLC | 1,962,720 | 10,795,000 | 14.90% | ||
| 3 | VICTORY CAPITAL MANAGEMENT INC | 1,735,405 | 9,544,000 | 13.17% | ||
| 4 | BVF INC/IL | 1,320,164 | 7,261,000 | 10.02% | ||
| 5 | FRANKLIN RESOURCES INC | 740,253 | 4,071,000 | 5.62% | ||
| 6 | BlackRock Fund Advisors | 443,790 | 2,441,000 | 3.37% | ||
| 7 | FMR LLC | 443,453 | 2,439,000 | 3.37% | ||
| 8 | Cormorant Asset Management, LP | 432,990 | 2,381,000 | 3.29% | ||
| 9 | VANGUARD GROUP INC | 318,862 | 1,754,000 | 2.42% | ||
| 10 | JPMORGAN CHASE & CO | 271,744 | 1,495,000 | 2.06% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 270,334 | 1,487,000 | 2.05% | ||
| 12 | STATE STREET CORP | 237,563 | 1,311,000 | 1.81% | ||
| 13 | PUTNAM INVESTMENTS LLC | 218,362 | 1,201,000 | 1.66% | ||
| 14 | NEXTHERA CAPITAL LP | 198,600 | 1,092,000 | 1.51% | ||
| 15 | Abingworth LLP | 197,300 | 1,075,000 | 1.48% | ||
| 16 | Alyeska Investment Group, L.P. | 167,493 | 921,000 | 1.27% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 159,490 | 877,000 | 1.21% | ||
| 18 | BAKER BROS. ADVISORS LP | 148,937 | 819,000 | 1.13% | ||
| 19 | NORTHERN TRUST CORP | 126,698 | 697,000 | 0.96% | ||
| 20 | PANAGORA ASSET MANAGEMENT INC | 123,835 | 681,000 | 0.94% | ||
| 21 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 115,000 | 633,000 | 0.87% | ||
| 22 | Spark Investment Management LLC | 106,700 | 586,000 | 0.81% | ||
| 23 | SPHERA FUNDS MANAGEMENT LTD. | 103,000 | 567,000 | 0.78% | ||
| 24 | OXFORD ASSET MANAGEMENT LLP | 102,692 | 565,000 | 0.78% | ||
| 25 | WELLS FARGO & COMPANY/MN | 101,621 | 559,000 | 0.77% | ||
| 26 | Weiss Multi-Strategy Advisers LLC | 100,000 | 550,000 | 0.76% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 96,729 | 532,000 | 0.73% | ||
| 28 | PERCEPTIVE ADVISORS LLC | 77,725 | 428,000 | 0.59% | ||
| 29 | BLACKROCK ADVISORS LLC | 66,849 | 368,000 | 0.51% | ||
| 30 | Bank of New York Mellon Corp | 63,610 | 350,000 | 0.48% | ||
| 31 | BlackRock Investment Management, LLC | 55,251 | 304,000 | 0.42% | ||
| 32 | D. E. Shaw & Co., Inc. | 49,180 | 270,000 | 0.37% | ||
| 33 | MORGAN STANLEY | 44,741 | 247,000 | 0.34% | ||
| 34 | RENAISSANCE TECHNOLOGIES LLC | 41,389 | 228,000 | 0.31% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 38,338 | 211,000 | 0.29% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,574 | 157,000 | 0.22% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,318 | 134,000 | 0.18% | ||
| 38 | TEACHERS ADVISORS, LLC | 22,510 | 124,000 | 0.17% | ||
| 39 | DLD ASSET MANAGEMENT, LP | 20,900 | 114,000 | 0.16% | Call | |
| 40 | BlackRock Group LTD | 17,129 | 94,000 | 0.13% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,243 | 90,000 | 0.12% | ||
| 42 | Squarepoint Ops LLC | 15,042 | 83,000 | 0.11% | ||
| 43 | JACOBS LEVY EQUITY MANAGEMENT, INC | 14,943 | 82,000 | 0.11% | ||
| 44 | RHUMBLINE ADVISERS | 12,151 | 67,000 | 0.09% | ||
| 45 | Focused Wealth Management, Inc | 11,665 | 64,000 | 0.09% | ||
| 46 | Paloma Partners Management Co | 11,510 | 63,000 | 0.09% | ||
| 47 | Nationwide Fund Advisors | 11,109 | 61,000 | 0.08% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 10,300 | 57,000 | 0.08% | ||
| 49 | RUSSELL INVESTMENTS GROUP, LTD. | 9,084 | 54,000 | 0.07% | ||
| 50 | BARCLAYS PLC | 9,158 | 51,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
