| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ProQuest Associates IV LLC | 1,962,720 | 39,411,000 | 18.84% | ||
| 2 | FMR LLC | 1,580,041 | 31,727,000 | 15.17% | ||
| 3 | RS INVESTMENT MANAGEMENT CO LLC | 1,108,576 | 22,260,000 | 10.64% | ||
| 4 | SECTORAL ASSET MANAGEMENT INC | 856,867 | 17,206,000 | 8.22% | ||
| 5 | FRANKLIN RESOURCES INC | 812,226 | 16,309,000 | 7.80% | ||
| 6 | BlackRock Fund Advisors | 539,686 | 10,837,000 | 5.18% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 327,432 | 6,575,000 | 3.14% | ||
| 8 | VANGUARD GROUP INC | 322,328 | 6,473,000 | 3.09% | ||
| 9 | PUTNAM INVESTMENTS LLC | 281,982 | 5,662,000 | 2.71% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 236,368 | 4,746,000 | 2.27% | ||
| 11 | JENNISON ASSOCIATES LLC | 203,452 | 4,085,000 | 1.95% | ||
| 12 | Cormorant Asset Management, LP | 189,000 | 3,795,000 | 1.81% | ||
| 13 | EVENTIDE ASSET MANAGEMENT, LLC | 180,000 | 3,614,000 | 1.73% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 153,000 | 3,072,000 | 1.47% | ||
| 15 | BAKER BROS. ADVISORS LP | 148,937 | 2,991,000 | 1.43% | ||
| 16 | JPMORGAN CHASE & CO | 140,600 | 2,824,000 | 1.35% | ||
| 17 | TEACHERS ADVISORS, LLC | 137,636 | 2,764,000 | 1.32% | ||
| 18 | NORTHERN TRUST CORP | 137,196 | 2,755,000 | 1.32% | ||
| 19 | STATE STREET CORP | 125,093 | 2,508,000 | 1.20% | ||
| 20 | PICTET ASSET MANAGEMENT LTD | 86,100 | 1,729,000 | 0.83% | ||
| 21 | Point72 Asset Management, L.P. | 75,772 | 1,522,000 | 0.73% | ||
| 22 | MARSHALL WACE, LLP | 72,812 | 1,462,000 | 0.70% | ||
| 23 | PANAGORA ASSET MANAGEMENT INC | 71,508 | 1,436,000 | 0.69% | ||
| 24 | BLACKROCK ADVISORS LLC | 60,413 | 1,213,000 | 0.58% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 59,887 | 1,202,000 | 0.57% | ||
| 26 | Bank of New York Mellon Corp | 59,669 | 1,198,000 | 0.57% | ||
| 27 | OXFORD ASSET MANAGEMENT LLP | 56,248 | 1,166,000 | 0.56% | ||
| 28 | NEXTHERA CAPITAL LP | 40,000 | 803,000 | 0.38% | ||
| 29 | BlackRock Investment Management, LLC | 38,857 | 780,000 | 0.37% | ||
| 30 | DEUTSCHE BANK AG\ | 38,763 | 777,000 | 0.37% | ||
| 31 | Vident Investment Advisory, LLC | 38,384 | 771,000 | 0.37% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 36,711 | 737,000 | 0.35% | ||
| 33 | ALPS ADVISORS INC | 26,534 | 533,000 | 0.25% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,973 | 421,000 | 0.20% | ||
| 35 | ProShare Advisors LLC | 17,848 | 358,000 | 0.17% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,243 | 327,000 | 0.16% | ||
| 37 | TD ASSET MANAGEMENT INC | 13,700 | 275,000 | 0.13% | ||
| 38 | Focused Wealth Management, Inc | 12,898 | 259,000 | 0.12% | ||
| 39 | FULLER & THALER ASSET MANAGEMENT, INC. | 12,100 | 243,000 | 0.12% | ||
| 40 | D. E. Shaw & Co., Inc. | 10,659 | 214,000 | 0.10% | ||
| 41 | Nationwide Fund Advisors | 10,578 | 212,000 | 0.10% | ||
| 42 | RHUMBLINE ADVISERS | 10,416 | 209,000 | 0.10% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 10,300 | 207,000 | 0.10% | ||
| 44 | CANADA LIFE ASSURANCE Co | 9,836 | 198,000 | 0.09% | ||
| 45 | METROPOLITAN LIFE INSURANCE CO/NY | 8,824 | 177,000 | 0.08% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,422 | 170,000 | 0.08% | ||
| 47 | Swiss National Bank | 8,400 | 169,000 | 0.08% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 6,628 | 133,000 | 0.06% | ||
| 49 | BlackRock Group LTD | 6,037 | 122,000 | 0.06% | ||
| 50 | CITADEL ADVISORS LLC | 5,546 | 111,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
