| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Versant Venture Management, LLC | 2,208,210 | 16,738,232 | 16.41% | ||
| 2 | ProQuest Associates IV LLC | 1,962,720 | 14,877,000 | 14.59% | ||
| 3 | VICTORY CAPITAL MANAGEMENT INC | 1,721,235 | 13,047,000 | 12.79% | ||
| 4 | BVF INC/IL | 1,200,000 | 9,096,000 | 8.92% | ||
| 5 | FRANKLIN RESOURCES INC | 812,226 | 6,157,000 | 6.04% | ||
| 6 | BlackRock Fund Advisors | 651,726 | 4,940,000 | 4.84% | ||
| 7 | FMR LLC | 503,679 | 3,818,000 | 3.74% | ||
| 8 | Cormorant Asset Management, LP | 432,990 | 3,282,000 | 3.22% | ||
| 9 | VANGUARD GROUP INC | 357,608 | 2,711,000 | 2.66% | ||
| 10 | NEXTHERA CAPITAL LP | 305,000 | 2,312,000 | 2.27% | ||
| 11 | JPMORGAN CHASE & CO | 271,802 | 2,060,000 | 2.02% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 254,772 | 1,931,000 | 1.89% | ||
| 13 | PUTNAM INVESTMENTS LLC | 253,386 | 1,921,000 | 1.88% | ||
| 14 | STATE STREET CORP | 219,448 | 1,667,000 | 1.63% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 203,000 | 1,539,000 | 1.51% | ||
| 16 | Abingworth LLP | 197,300 | 1,494,000 | 1.46% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 180,000 | 1,364,000 | 1.34% | ||
| 18 | Alyeska Investment Group, L.P. | 166,159 | 1,259,000 | 1.23% | ||
| 19 | BAKER BROS. ADVISORS LP | 148,937 | 1,129,000 | 1.11% | ||
| 20 | Point72 Asset Management, L.P. | 132,100 | 1,001,000 | 0.98% | ||
| 21 | NORTHERN TRUST CORP | 120,219 | 911,000 | 0.89% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 116,500 | 883,000 | 0.87% | ||
| 23 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 115,000 | 872,000 | 0.85% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 91,096 | 690,000 | 0.68% | ||
| 25 | PANAGORA ASSET MANAGEMENT INC | 84,585 | 641,000 | 0.63% | ||
| 26 | PERCEPTIVE ADVISORS LLC | 77,725 | 589,000 | 0.58% | ||
| 27 | DEUTSCHE BANK AG\ | 70,103 | 530,000 | 0.52% | ||
| 28 | BLACKROCK ADVISORS LLC | 62,673 | 475,000 | 0.47% | ||
| 29 | Bank of New York Mellon Corp | 57,840 | 439,000 | 0.43% | ||
| 30 | BlackRock Investment Management, LLC | 53,161 | 403,000 | 0.40% | ||
| 31 | MONASHEE INVESTMENT MANAGEMENT LLC | 50,000 | 379,000 | 0.37% | PRN | |
| 32 | DAFNA Capital Management LLC | 40,000 | 303,000 | 0.30% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 39,590 | 300,000 | 0.29% | ||
| 34 | Spark Investment Management LLC | 31,100 | 235,000 | 0.23% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,374 | 223,000 | 0.22% | ||
| 36 | ALPS ADVISORS INC | 25,720 | 195,000 | 0.19% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 23,039 | 175,000 | 0.17% | ||
| 38 | TEACHERS ADVISORS, LLC | 19,304 | 146,000 | 0.14% | ||
| 39 | Focused Wealth Management, Inc | 18,968 | 144,000 | 0.14% | ||
| 40 | Swiss National Bank | 17,300 | 131,000 | 0.13% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,243 | 124,000 | 0.12% | ||
| 42 | GOLDMAN SACHS GROUP INC | 15,378 | 117,000 | 0.11% | ||
| 43 | CREDIT SUISSE AG/ | 15,489 | 117,000 | 0.11% | ||
| 44 | ProShare Advisors LLC | 13,828 | 105,000 | 0.10% | ||
| 45 | Nationwide Fund Advisors | 11,309 | 86,000 | 0.08% | ||
| 46 | Tower Research Capital LLC (TRC) | 11,134 | 85,000 | 0.08% | ||
| 47 | RHUMBLINE ADVISERS | 10,499 | 80,000 | 0.08% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 10,300 | 78,000 | 0.08% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 6,449 | 48,883 | 0.05% | ||
| 50 | WELLS FARGO & COMPANY/MN | 4,200 | 32,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
