| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ProQuest Associates IV LLC | 1,962,720 | 16,016,000 | 19.45% | ||
| 2 | RS INVESTMENT MANAGEMENT CO LLC | 1,227,595 | 10,017,000 | 12.17% | ||
| 3 | PICTET ASSET MANAGEMENT LTD | 748,145 | 9,389,000 | 11.40% | ||
| 4 | FRANKLIN RESOURCES INC | 812,226 | 6,628,000 | 8.05% | ||
| 5 | FMR LLC | 734,641 | 5,995,000 | 7.28% | ||
| 6 | BlackRock Fund Advisors | 549,736 | 4,486,000 | 5.45% | ||
| 7 | Cormorant Asset Management, LP | 432,990 | 3,533,000 | 4.29% | ||
| 8 | VANGUARD GROUP INC | 334,933 | 2,734,000 | 3.32% | ||
| 9 | PUTNAM INVESTMENTS LLC | 282,683 | 2,307,000 | 2.80% | ||
| 10 | JPMORGAN CHASE & CO | 246,675 | 2,014,000 | 2.45% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 229,546 | 1,873,000 | 2.27% | ||
| 12 | STATE STREET CORP | 207,670 | 1,694,000 | 2.06% | ||
| 13 | Abingworth LLP | 197,300 | 1,610,000 | 1.96% | ||
| 14 | EVENTIDE ASSET MANAGEMENT, LLC | 180,000 | 1,469,000 | 1.78% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 153,000 | 1,248,000 | 1.52% | ||
| 16 | BAKER BROS. ADVISORS LP | 148,937 | 1,215,000 | 1.48% | ||
| 17 | NORTHERN TRUST CORP | 126,648 | 1,034,000 | 1.26% | ||
| 18 | TFS CAPITAL LLC | 102,685 | 838,000 | 1.02% | ||
| 19 | PANAGORA ASSET MANAGEMENT INC | 96,644 | 789,000 | 0.96% | ||
| 20 | NEXTHERA CAPITAL LP | 85,138 | 695,000 | 0.84% | ||
| 21 | Spark Investment Management LLC | 77,500 | 632,000 | 0.77% | ||
| 22 | Point72 Asset Management, L.P. | 70,572 | 576,000 | 0.70% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 61,924 | 505,000 | 0.61% | ||
| 24 | BLACKROCK ADVISORS LLC | 60,355 | 492,000 | 0.60% | ||
| 25 | Bank of New York Mellon Corp | 59,438 | 484,000 | 0.59% | ||
| 26 | OXFORD ASSET MANAGEMENT LLP | 58,083 | 474,000 | 0.58% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 47,935 | 391,000 | 0.47% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 43,523 | 355,000 | 0.43% | ||
| 29 | BlackRock Investment Management, LLC | 41,876 | 342,000 | 0.42% | ||
| 30 | EMERALD ACQUISITION LTD. | 35,867 | 292,000 | 0.35% | ||
| 31 | DEUTSCHE BANK AG\ | 32,864 | 267,000 | 0.32% | ||
| 32 | ALPS ADVISORS INC | 28,310 | 231,000 | 0.28% | ||
| 33 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 26,452 | 215,000 | 0.26% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,474 | 192,000 | 0.23% | ||
| 35 | TEACHERS ADVISORS, LLC | 19,304 | 158,000 | 0.19% | ||
| 36 | ProShare Advisors LLC | 16,372 | 134,000 | 0.16% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,243 | 133,000 | 0.16% | ||
| 38 | Focused Wealth Management, Inc | 15,868 | 129,000 | 0.16% | ||
| 39 | CREDIT SUISSE AG/ | 13,524 | 110,000 | 0.13% | ||
| 40 | Swiss National Bank | 12,500 | 102,000 | 0.12% | ||
| 41 | Nationwide Fund Advisors | 10,378 | 85,000 | 0.10% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 10,300 | 84,000 | 0.10% | ||
| 43 | RHUMBLINE ADVISERS | 10,089 | 82,000 | 0.10% | ||
| 44 | AMERICAN INTERNATIONAL GROUP, INC. | 6,440 | 52,550 | 0.06% | ||
| 45 | MORGAN STANLEY | 4,828 | 40,000 | 0.05% | ||
| 46 | Cubist Systematic Strategies, LLC | 4,550 | 37,000 | 0.04% | ||
| 47 | WELLS FARGO & COMPANY/MN | 4,208 | 34,000 | 0.04% | ||
| 48 | BlackRock Finance, Inc. | 3,163 | 26,000 | 0.03% | ||
| 49 | BlackRock Group LTD | 2,713 | 22,000 | 0.03% | ||
| 50 | CANADA LIFE ASSURANCE Co | 2,745 | 22,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
