| 1 |
COLUMN GROUP L P |
3,161,942 |
38,576,000 |
23.05% |
|
|
| 2 |
ProQuest Associates IV LLC |
1,962,720 |
23,945,000 |
14.31% |
|
|
| 3 |
FMR LLC |
1,580,041 |
19,277,000 |
11.52% |
|
|
| 4 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,112,809 |
13,576,000 |
8.11% |
|
|
| 5 |
RS INVESTMENT MANAGEMENT CO LLC |
985,666 |
12,025,000 |
7.18% |
|
|
| 6 |
SECTORAL ASSET MANAGEMENT INC |
845,867 |
10,320,000 |
6.17% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
836,426 |
10,204,000 |
6.10% |
|
|
| 8 |
VANGUARD GROUP INC |
299,919 |
3,659,000 |
2.19% |
|
|
| 9 |
BlackRock Fund Advisors |
296,469 |
3,617,000 |
2.16% |
|
|
| 10 |
PUTNAM INVESTMENTS LLC |
282,990 |
3,453,000 |
2.06% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
210,962 |
2,574,000 |
1.54% |
|
|
| 12 |
JENNISON ASSOCIATES LLC |
202,683 |
2,473,000 |
1.48% |
|
|
| 13 |
Cormorant Asset Management, LP |
189,000 |
2,306,000 |
1.38% |
|
|
| 14 |
SPHERA FUNDS MANAGEMENT LTD. |
170,000 |
2,074,000 |
1.24% |
|
|
| 15 |
EVENTIDE ASSET MANAGEMENT, LLC |
154,501 |
1,885,000 |
1.13% |
|
|
| 16 |
JPMORGAN CHASE & CO |
152,425 |
1,860,000 |
1.11% |
|
|
| 17 |
BAKER BROS. ADVISORS LP |
148,937 |
1,817,000 |
1.09% |
|
|
| 18 |
NORTHERN TRUST CORP |
121,154 |
1,478,000 |
0.88% |
|
|
| 19 |
STATE STREET CORP |
108,689 |
1,324,000 |
0.79% |
|
|
| 20 |
TEACHERS ADVISORS, LLC |
107,196 |
1,308,000 |
0.78% |
|
|
| 21 |
PICTET ASSET MANAGEMENT LTD |
75,100 |
916,000 |
0.55% |
|
|
| 22 |
Iguana Healthcare Management, LLC |
75,000 |
915,000 |
0.55% |
|
|
| 23 |
MARSHALL WACE, LLP |
72,812 |
888,000 |
0.53% |
|
|
| 24 |
PANAGORA ASSET MANAGEMENT INC |
69,969 |
854,000 |
0.51% |
|
|
| 25 |
BLACKROCK ADVISORS LLC |
62,282 |
760,000 |
0.45% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
57,795 |
705,000 |
0.42% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
39,250 |
479,000 |
0.29% |
|
|
| 28 |
BlackRock Investment Management, LLC |
38,788 |
473,000 |
0.28% |
|
|
| 29 |
Bank of New York Mellon Corp |
38,241 |
467,000 |
0.28% |
|
|
| 30 |
DEUTSCHE BANK AG\ |
38,292 |
466,000 |
0.28% |
|
|
| 31 |
Nationwide Fund Advisors |
35,208 |
430,000 |
0.26% |
|
|
| 32 |
TD ASSET MANAGEMENT INC |
32,800 |
400,000 |
0.24% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
31,027 |
379,000 |
0.23% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
20,573 |
251,000 |
0.15% |
|
|
| 35 |
SABBY MANAGEMENT, LLC |
20,000 |
244,000 |
0.15% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
16,243 |
199,000 |
0.12% |
|
|
| 37 |
Focused Wealth Management, Inc |
10,646 |
130,000 |
0.08% |
|
|
| 38 |
NEW YORK STATE COMMON RETIREMENT FUND |
10,300 |
126,000 |
0.08% |
|
|
| 39 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
8,422 |
102,000 |
0.06% |
|
|
| 40 |
Swiss National Bank |
8,400 |
102,000 |
0.06% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,640 |
81,000 |
0.05% |
|
|
| 42 |
BlackRock Group LTD |
6,037 |
74,000 |
0.04% |
|
|
| 43 |
WELLS FARGO & COMPANY/MN |
4,711 |
57,000 |
0.03% |
|
|
| 44 |
BNP PARIBAS FINANCIAL MARKETS |
2,547 |
31,073 |
0.02% |
|
|
| 45 |
GROUP ONE TRADING LLC |
2,017 |
25,000 |
0.01% |
|
|
| 46 |
MORGAN STANLEY |
1,935 |
24,000 |
0.01% |
|
|
| 47 |
BlackRock Finance, Inc. |
1,261 |
15,000 |
0.01% |
|
|
| 48 |
TEACHER RETIREMENT SYSTEM OF TEXAS |
978 |
12,000 |
0.01% |
|
|
| 49 |
BlackRock Japan Co. Ltd |
914 |
11,000 |
0.01% |
|
|
| 50 |
ROYAL BANK OF CANADA |
482 |
6,000 |
0.00% |
|
|
