| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 2,843,480 | 59,798,000 | 15.73% | ||
| 2 | FMR LLC | 2,749,021 | 57,812,000 | 15.21% | ||
| 3 | Capital World Investors | 2,028,000 | 42,649,000 | 11.22% | ||
| 4 | SV Health Investors, LLC | 1,932,607 | 40,643,000 | 10.69% | ||
| 5 | FEDERATED HERMES, INC. | 1,359,700 | 28,594,000 | 7.52% | ||
| 6 | Polaris Venture Management Co. V, L.L.C. | 1,230,009 | 25,867,000 | 6.81% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 891,285 | 18,745,000 | 4.93% | ||
| 8 | JENNISON ASSOCIATES LLC | 766,279 | 16,115,000 | 4.24% | ||
| 9 | Lamond Capital Partners LLC | 711,533 | 14,964,000 | 3.94% | ||
| 10 | BlackRock Fund Advisors | 345,336 | 7,262,000 | 1.91% | ||
| 11 | DRIEHAUS CAPITAL MANAGEMENT LLC | 335,498 | 7,056,000 | 1.86% | ||
| 12 | VANGUARD GROUP INC | 310,532 | 6,531,000 | 1.72% | ||
| 13 | Pentwater Capital Management LP | 295,690 | 6,218,000 | 1.64% | ||
| 14 | FARALLON CAPITAL MANAGEMENT LLC | 215,000 | 4,521,000 | 1.19% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 178,196 | 3,747,000 | 0.99% | ||
| 16 | NOTTINGHAM ADVISORS, INC. | 171,985 | 3,617,000 | 0.95% | ||
| 17 | SPHERA FUNDS MANAGEMENT LTD. | 160,000 | 3,365,000 | 0.89% | ||
| 18 | STATE STREET CORP | 124,900 | 2,626,000 | 0.69% | ||
| 19 | Portolan Capital Management, LLC | 122,518 | 2,577,000 | 0.68% | ||
| 20 | SABBY MANAGEMENT, LLC | 100,000 | 2,103,000 | 0.55% | ||
| 21 | DEUTSCHE BANK AG\ | 99,535 | 2,092,000 | 0.55% | ||
| 22 | D. E. Shaw & Co., Inc. | 81,628 | 1,717,000 | 0.45% | ||
| 23 | NORTHERN TRUST CORP | 67,552 | 1,420,000 | 0.37% | ||
| 24 | A.R.T. Advisors, LLC | 67,399 | 1,417,000 | 0.37% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 64,051 | 1,346,000 | 0.35% | ||
| 26 | BAILARD, INC. | 55,000 | 1,157,000 | 0.30% | ||
| 27 | Bank of New York Mellon Corp | 53,782 | 1,131,000 | 0.30% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 52,093 | 1,096,000 | 0.29% | ||
| 29 | BlackRock Investment Management, LLC | 46,127 | 970,000 | 0.26% | ||
| 30 | PDT Partners, LLC | 39,887 | 839,000 | 0.22% | ||
| 31 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 35,830 | 754,000 | 0.20% | ||
| 32 | FRED ALGER MANAGEMENT, LLC | 35,307 | 743,000 | 0.20% | ||
| 33 | CREDIT SUISSE AG/ | 31,681 | 667,000 | 0.18% | ||
| 34 | RUSSELL FRANK CO/ | 30,078 | 633,000 | 0.17% | ||
| 35 | MONASHEE INVESTMENT MANAGEMENT LLC | 28,834 | 606,000 | 0.16% | PRN | |
| 36 | ELLINGTON MANAGEMENT GROUP LLC | 28,068 | 590,000 | 0.16% | ||
| 37 | ALPS ADVISORS INC | 24,483 | 515,000 | 0.14% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,803 | 501,000 | 0.13% | ||
| 39 | Amici Capital, LLC | 20,000 | 421,000 | 0.11% | ||
| 40 | TEACHERS ADVISORS, LLC | 19,014 | 400,000 | 0.11% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,570 | 391,000 | 0.10% | ||
| 42 | Rotella Capital Management, Inc. | 18,461 | 388,000 | 0.10% | ||
| 43 | CITADEL ADVISORS LLC | 17,682 | 372,000 | 0.10% | ||
| 44 | TUDOR INVESTMENT CORP ET AL | 17,663 | 371,000 | 0.10% | ||
| 45 | MORGAN STANLEY | 17,604 | 370,000 | 0.10% | ||
| 46 | WELLS FARGO & COMPANY/MN | 16,191 | 340,000 | 0.09% | ||
| 47 | Trexquant Investment LP | 15,700 | 329,000 | 0.09% | ||
| 48 | Capital Impact Advisors, LLC | 13,211 | 278,000 | 0.07% | ||
| 49 | Nationwide Fund Advisors | 13,119 | 276,000 | 0.07% | ||
| 50 | GOLDMAN SACHS GROUP INC | 12,993 | 273,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
