| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 3,216,881 | 26,925,000 | 18.28% | ||
| 2 | FMR LLC | 2,620,768 | 21,936,000 | 14.89% | ||
| 3 | Versant Venture Management, LLC | 2,215,384 | 18,542,764 | 12.59% | ||
| 4 | SV Health Investors, LLC | 1,605,207 | 13,436,000 | 9.12% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 970,936 | 8,127,000 | 5.52% | ||
| 6 | Polaris Venture Management Co. V, L.L.C. | 788,723 | 6,602,000 | 4.48% | ||
| 7 | VANGUARD GROUP INC | 727,574 | 6,090,000 | 4.14% | ||
| 8 | BlackRock Fund Advisors | 574,555 | 4,809,000 | 3.27% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 536,703 | 4,492,000 | 3.05% | ||
| 10 | COLUMBUS CIRCLE INVESTORS | 470,090 | 3,935,000 | 2.67% | ||
| 11 | MORGAN STANLEY | 328,686 | 2,750,000 | 1.87% | ||
| 12 | BAILARD, INC. | 246,752 | 2,065,000 | 1.40% | ||
| 13 | STATE STREET CORP | 238,921 | 2,000,000 | 1.36% | ||
| 14 | SCHONFELD STRATEGIC ADVISORS LLC | 228,901 | 1,916,000 | 1.30% | ||
| 15 | NORTHERN TRUST CORP | 199,440 | 1,670,000 | 1.13% | ||
| 16 | ROYAL BANK OF CANADA | 173,374 | 1,451,000 | 0.99% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 145,100 | 1,214,000 | 0.82% | ||
| 18 | NOTTINGHAM ADVISORS, INC. | 144,446 | 1,209,000 | 0.82% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 138,732 | 1,161,000 | 0.79% | ||
| 20 | DEUTSCHE BANK AG\ | 121,892 | 1,018,000 | 0.69% | ||
| 21 | DELTEC ASSET MANAGEMENT LLC | 115,000 | 963,000 | 0.65% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 109,400 | 916,000 | 0.62% | Call | |
| 23 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 100,000 | 837,000 | 0.57% | ||
| 24 | Opaleye Management Inc. | 93,600 | 783,000 | 0.53% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 75,785 | 634,000 | 0.43% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,400 | 631,000 | 0.43% | Put | |
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,685 | 608,000 | 0.41% | ||
| 28 | COWEN INC. | 71,375 | 597,000 | 0.41% | ||
| 29 | Bank of New York Mellon Corp | 71,057 | 595,000 | 0.40% | ||
| 30 | BlackRock Investment Management, LLC | 70,932 | 594,000 | 0.40% | ||
| 31 | EDMOND DE ROTHSCHILD HOLDING S.A. | 70,000 | 586,000 | 0.40% | ||
| 32 | WELLS FARGO & COMPANY/MN | 69,601 | 582,000 | 0.40% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 63,370 | 530,000 | 0.36% | ||
| 34 | Squarepoint Ops LLC | 60,985 | 510,000 | 0.35% | ||
| 35 | CREDIT SUISSE AG/ | 53,183 | 446,000 | 0.30% | ||
| 36 | A.R.T. Advisors, LLC | 53,400 | 446,000 | 0.30% | ||
| 37 | GOLDMAN SACHS GROUP INC | 49,898 | 418,000 | 0.28% | ||
| 38 | Rhenman & Partners Asset Management AB | 40,000 | 335,000 | 0.23% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 38,470 | 322,000 | 0.22% | ||
| 40 | TEACHERS ADVISORS, LLC | 37,318 | 312,000 | 0.21% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,839 | 308,000 | 0.21% | ||
| 42 | CUTLER GROUP LLC / CA | 36,544 | 305,000 | 0.21% | ||
| 43 | Dynamic Technology Lab Private Ltd | 35,458 | 296,000 | 0.20% | ||
| 44 | NumerixS Investment Technologies Inc | 35,200 | 295,000 | 0.20% | ||
| 45 | CORRADO ADVISORS, LLC | 31,020 | 260,000 | 0.18% | ||
| 46 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 30,181 | 253,000 | 0.17% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 27,300 | 229,000 | 0.16% | ||
| 48 | BANK OF MONTREAL /CAN/ | 23,308 | 217,000 | 0.15% | ||
| 49 | ALPS ADVISORS INC | 23,909 | 200,000 | 0.14% | ||
| 50 | Trexquant Investment LP | 21,663 | 181,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
