| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,992,627 | 42,076,000 | 13.34% | ||
| 2 | Capital Research Global Investors | 2,843,480 | 39,979,000 | 12.67% | ||
| 3 | Versant Venture Management, LLC | 2,215,384 | 31,148,299 | 9.87% | ||
| 4 | Capital World Investors | 2,028,000 | 28,514,000 | 9.04% | ||
| 5 | SV Health Investors, LLC | 1,932,607 | 27,172,000 | 8.61% | ||
| 6 | FEDERATED HERMES, INC. | 1,718,480 | 24,162,000 | 7.66% | ||
| 7 | Lamond Capital Partners LLC | 1,233,285 | 17,340,000 | 5.50% | ||
| 8 | Polaris Venture Management Co. V, L.L.C. | 1,230,009 | 17,294,000 | 5.48% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 916,362 | 12,884,000 | 4.08% | ||
| 10 | JENNISON ASSOCIATES LLC | 770,232 | 10,829,000 | 3.43% | ||
| 11 | Portolan Capital Management, LLC | 492,225 | 6,921,000 | 2.19% | ||
| 12 | VANGUARD GROUP INC | 429,415 | 6,037,000 | 1.91% | ||
| 13 | BlackRock Fund Advisors | 392,453 | 5,518,000 | 1.75% | ||
| 14 | ALPS ADVISORS INC | 38,665 | 5,436,000 | 1.72% | ||
| 15 | FARALLON CAPITAL MANAGEMENT LLC | 271,200 | 3,813,000 | 1.21% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 260,822 | 3,667,000 | 1.16% | ||
| 17 | ORBIMED ADVISORS LLC | 208,900 | 2,937,000 | 0.93% | ||
| 18 | DRIEHAUS CAPITAL MANAGEMENT LLC | 188,133 | 2,645,000 | 0.84% | ||
| 19 | NOTTINGHAM ADVISORS, INC. | 185,235 | 2,604,000 | 0.83% | ||
| 20 | STATE STREET CORP | 176,949 | 2,485,000 | 0.79% | ||
| 21 | NORTHERN TRUST CORP | 156,476 | 2,200,000 | 0.70% | ||
| 22 | LORD, ABBETT & CO. LLC | 113,000 | 1,589,000 | 0.50% | ||
| 23 | SABBY MANAGEMENT, LLC | 105,190 | 1,479,000 | 0.47% | ||
| 24 | DEUTSCHE BANK AG\ | 100,496 | 1,412,000 | 0.45% | ||
| 25 | BAILARD, INC. | 92,000 | 1,294,000 | 0.41% | ||
| 26 | Iguana Healthcare Management, LLC | 75,000 | 1,055,000 | 0.33% | ||
| 27 | Bank of New York Mellon Corp | 72,724 | 1,023,000 | 0.32% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 68,320 | 960,000 | 0.30% | ||
| 29 | COLUMBUS CIRCLE INVESTORS | 66,112 | 930,000 | 0.29% | ||
| 30 | Nicholas Investment Partners, LP | 62,669 | 881,000 | 0.28% | ||
| 31 | ALLIANCEBERNSTEIN L.P. | 58,544 | 823,000 | 0.26% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 57,972 | 815,000 | 0.26% | ||
| 33 | BlackRock Investment Management, LLC | 52,259 | 735,000 | 0.23% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,600 | 711,000 | 0.23% | Put | |
| 35 | FRED ALGER MANAGEMENT, LLC | 35,307 | 496,000 | 0.16% | ||
| 36 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 34,180 | 481,000 | 0.15% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,700 | 404,000 | 0.13% | Call | |
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,303 | 384,000 | 0.12% | ||
| 39 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 27,000 | 380,000 | 0.12% | ||
| 40 | EDMOND DE ROTHSCHILD HOLDING S.A. | 27,000 | 380,000 | 0.12% | ||
| 41 | WELLS FARGO & COMPANY/MN | 21,454 | 302,000 | 0.10% | ||
| 42 | Amici Capital, LLC | 20,000 | 281,000 | 0.09% | ||
| 43 | TEACHERS ADVISORS, LLC | 19,014 | 267,000 | 0.08% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,570 | 262,000 | 0.08% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 16,240 | 228,000 | 0.07% | ||
| 46 | Nationwide Fund Advisors | 13,975 | 196,000 | 0.06% | ||
| 47 | Capital Impact Advisors, LLC | 13,211 | 186,000 | 0.06% | ||
| 48 | Swiss National Bank | 13,000 | 183,000 | 0.06% | ||
| 49 | RHUMBLINE ADVISERS | 11,769 | 165,000 | 0.05% | ||
| 50 | D. E. Shaw & Co., Inc. | 11,567 | 163,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
