| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,514,930 | 24,148,000 | 18.72% | ||
| 2 | JENNISON ASSOCIATES LLC | 3,004,521 | 20,641,000 | 16.00% | ||
| 3 | Versant Venture Management, LLC | 2,215,384 | 15,219,688 | 11.80% | ||
| 4 | SV Health Investors, LLC | 1,932,607 | 13,277,000 | 10.29% | ||
| 5 | Polaris Venture Management Co. V, L.L.C. | 998,713 | 6,861,000 | 5.32% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 982,176 | 6,748,000 | 5.23% | ||
| 7 | BlackRock Fund Advisors | 824,426 | 5,664,000 | 4.39% | ||
| 8 | VANGUARD GROUP INC | 749,874 | 5,152,000 | 3.99% | ||
| 9 | MORGAN STANLEY | 573,309 | 3,938,000 | 3.05% | ||
| 10 | COLUMBUS CIRCLE INVESTORS | 491,204 | 3,375,000 | 2.62% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 435,863 | 2,994,000 | 2.32% | ||
| 12 | BAILARD, INC. | 314,752 | 2,162,000 | 1.68% | ||
| 13 | FEDERATED HERMES, INC. | 261,700 | 1,798,000 | 1.39% | ||
| 14 | NORTHERN TRUST CORP | 210,345 | 1,445,000 | 1.12% | ||
| 15 | STATE STREET CORP | 196,160 | 1,350,000 | 1.05% | ||
| 16 | NOTTINGHAM ADVISORS, INC. | 189,266 | 1,300,000 | 1.01% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 178,800 | 1,228,000 | 0.95% | Call | |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 136,069 | 934,000 | 0.72% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 106,400 | 731,000 | 0.57% | Put | |
| 20 | DEUTSCHE BANK AG\ | 100,961 | 693,000 | 0.54% | ||
| 21 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 100,000 | 687,000 | 0.53% | ||
| 22 | ROYAL BANK OF CANADA | 95,415 | 655,000 | 0.51% | ||
| 23 | Bank of New York Mellon Corp | 84,199 | 578,000 | 0.45% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 76,935 | 529,000 | 0.41% | ||
| 25 | GOLDMAN SACHS GROUP INC | 72,183 | 496,000 | 0.38% | ||
| 26 | BlackRock Investment Management, LLC | 70,728 | 486,000 | 0.38% | ||
| 27 | EDMOND DE ROTHSCHILD HOLDING S.A. | 70,000 | 481,000 | 0.37% | ||
| 28 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 70,000 | 481,000 | 0.37% | ||
| 29 | COWEN INC. | 68,400 | 470,000 | 0.36% | ||
| 30 | Polar Capital LLP | 57,500 | 395,000 | 0.31% | ||
| 31 | Rhenman & Partners Asset Management AB | 40,000 | 274,800 | 0.21% | ||
| 32 | WELLS FARGO & COMPANY/MN | 38,680 | 266,000 | 0.21% | ||
| 33 | SABBY MANAGEMENT, LLC | 38,100 | 262,000 | 0.20% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,939 | 261,000 | 0.20% | ||
| 35 | ALPS ADVISORS INC | 31,643 | 217,000 | 0.17% | ||
| 36 | CREDIT SUISSE AG/ | 27,614 | 189,000 | 0.15% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 27,300 | 188,000 | 0.15% | ||
| 38 | TEACHERS ADVISORS, LLC | 25,268 | 174,000 | 0.13% | ||
| 39 | Spot Trading L.L.C | 25,000 | 172,000 | 0.13% | Put | |
| 40 | CUTLER GROUP LLC / CA | 20,903 | 143,000 | 0.11% | ||
| 41 | SCHONFELD STRATEGIC ADVISORS LLC | 20,903 | 143,000 | 0.11% | ||
| 42 | Swiss National Bank | 19,000 | 131,000 | 0.10% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,570 | 128,000 | 0.10% | ||
| 44 | ProShare Advisors LLC | 17,423 | 120,000 | 0.09% | ||
| 45 | ELLINGTON MANAGEMENT GROUP LLC | 16,900 | 116,000 | 0.09% | ||
| 46 | D. E. Shaw & Co., Inc. | 15,147 | 104,000 | 0.08% | ||
| 47 | Virtu KCG Holdings LLC | 13,414 | 92,000 | 0.07% | ||
| 48 | RHUMBLINE ADVISERS | 13,284 | 91,000 | 0.07% | ||
| 49 | BlackRock Group LTD | 13,142 | 90,000 | 0.07% | ||
| 50 | NEW YORK STATE COMMON RETIREMENT FUND | 12,800 | 88,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
