| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,179,557 | 30,715,000 | 15.21% | ||
| 2 | Capital Research Global Investors | 2,865,358 | 27,679,000 | 13.70% | ||
| 3 | Versant Venture Management, LLC | 2,215,384 | 21,400,609 | 10.59% | ||
| 4 | Capital World Investors | 2,028,000 | 19,590,000 | 9.70% | ||
| 5 | SV Health Investors, LLC | 1,932,607 | 18,669,000 | 9.24% | ||
| 6 | FEDERATED HERMES, INC. | 1,647,233 | 15,912,000 | 7.88% | ||
| 7 | JENNISON ASSOCIATES LLC | 1,329,345 | 12,841,000 | 6.36% | ||
| 8 | Polaris Venture Management Co. V, L.L.C. | 1,230,009 | 11,882,000 | 5.88% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 864,768 | 8,353,000 | 4.14% | ||
| 10 | BlackRock Fund Advisors | 703,729 | 6,798,000 | 3.37% | ||
| 11 | VANGUARD GROUP INC | 455,516 | 4,400,000 | 2.18% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 261,860 | 2,530,000 | 1.25% | ||
| 13 | BAILARD, INC. | 219,752 | 2,123,000 | 1.05% | ||
| 14 | STATE STREET CORP | 205,586 | 1,989,000 | 0.98% | ||
| 15 | COLUMBUS CIRCLE INVESTORS | 188,502 | 1,821,000 | 0.90% | ||
| 16 | NOTTINGHAM ADVISORS, INC. | 182,266 | 1,708,000 | 0.85% | ||
| 17 | NORTHERN TRUST CORP | 163,049 | 1,575,000 | 0.78% | ||
| 18 | COWEN INC. | 145,700 | 1,407,000 | 0.70% | ||
| 19 | DEUTSCHE BANK AG\ | 99,629 | 961,000 | 0.48% | ||
| 20 | D. E. Shaw & Co., Inc. | 89,730 | 867,000 | 0.43% | ||
| 21 | BALYASNY ASSET MANAGEMENT L.P. | 85,000 | 821,000 | 0.41% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 70,396 | 680,000 | 0.34% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,900 | 617,000 | 0.31% | Call | |
| 24 | Bank of New York Mellon Corp | 60,747 | 586,000 | 0.29% | ||
| 25 | BlackRock Investment Management, LLC | 53,813 | 520,000 | 0.26% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,468 | 468,000 | 0.23% | ||
| 27 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 45,000 | 435,000 | 0.22% | ||
| 28 | EDMOND DE ROTHSCHILD HOLDING S.A. | 45,000 | 435,000 | 0.22% | ||
| 29 | WELLS FARGO & COMPANY/MN | 44,353 | 429,000 | 0.21% | ||
| 30 | Rhenman & Partners Asset Management AB | 40,000 | 386,000 | 0.19% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,450 | 313,000 | 0.15% | ||
| 32 | Polar Capital LLP | 30,000 | 290,000 | 0.14% | ||
| 33 | ALPS ADVISORS INC | 27,816 | 269,000 | 0.13% | ||
| 34 | MORGAN STANLEY | 22,822 | 220,000 | 0.11% | ||
| 35 | TEACHERS ADVISORS, LLC | 21,432 | 207,000 | 0.10% | ||
| 36 | ProShare Advisors LLC | 20,009 | 193,000 | 0.10% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,570 | 180,000 | 0.09% | ||
| 38 | Swiss National Bank | 16,800 | 156,000 | 0.08% | ||
| 39 | CANADA LIFE ASSURANCE Co | 16,146 | 155,000 | 0.08% | ||
| 40 | RHUMBLINE ADVISERS | 14,954 | 144,000 | 0.07% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,100 | 136,000 | 0.07% | Put | |
| 42 | BlackRock Group LTD | 13,142 | 127,000 | 0.06% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 12,800 | 124,000 | 0.06% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 12,000 | 116,000 | 0.06% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,183 | 105,000 | 0.05% | ||
| 46 | CITIGROUP INC | 10,522 | 102,000 | 0.05% | ||
| 47 | DekaBank Deutsche Girozentrale | 10,000 | 94,000 | 0.05% | ||
| 48 | Nationwide Fund Advisors | 9,608 | 93,000 | 0.05% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 7,632 | 74,000 | 0.04% | ||
| 50 | PURA VIDA INVESTMENTS, LLC | 6,000 | 58,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
