| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,711,552 | 18,372,000 | 19.23% | ||
| 2 | JENNISON ASSOCIATES LLC | 2,972,606 | 14,714,000 | 15.40% | ||
| 3 | Versant Venture Management, LLC | 2,215,384 | 10,966,151 | 11.48% | ||
| 4 | SV Health Investors, LLC | 1,932,607 | 9,566,000 | 10.02% | ||
| 5 | FEDERATED HERMES, INC. | 1,396,287 | 6,912,000 | 7.24% | ||
| 6 | Polaris Venture Management Co. V, L.L.C. | 998,713 | 4,944,000 | 5.18% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 961,136 | 4,758,000 | 4.98% | ||
| 8 | BlackRock Fund Advisors | 775,611 | 3,839,000 | 4.02% | ||
| 9 | VANGUARD GROUP INC | 479,309 | 2,373,000 | 2.48% | ||
| 10 | PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 353,464 | 1,750,000 | 1.83% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 294,608 | 1,458,000 | 1.53% | ||
| 12 | COLUMBUS CIRCLE INVESTORS | 278,785 | 1,380,000 | 1.44% | ||
| 13 | Opaleye Management Inc. | 260,000 | 1,287,000 | 1.35% | ||
| 14 | BAILARD, INC. | 219,752 | 1,088,000 | 1.14% | ||
| 15 | STATE STREET CORP | 205,309 | 1,014,000 | 1.06% | ||
| 16 | NORTHERN TRUST CORP | 193,804 | 959,000 | 1.00% | ||
| 17 | NOTTINGHAM ADVISORS, INC. | 189,266 | 937,000 | 0.98% | ||
| 18 | DEUTSCHE BANK AG\ | 128,187 | 634,000 | 0.66% | ||
| 19 | COWEN INC. | 126,904 | 628,000 | 0.66% | ||
| 20 | MORGAN STANLEY | 98,606 | 488,000 | 0.51% | ||
| 21 | ACADIAN ASSET MANAGEMENT LLC | 85,259 | 422,000 | 0.44% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 76,935 | 381,000 | 0.40% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 76,212 | 377,000 | 0.39% | ||
| 24 | Polar Capital LLP | 74,873 | 371,000 | 0.39% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73,800 | 365,000 | 0.38% | Call | |
| 26 | EDMOND DE ROTHSCHILD HOLDING S.A. | 70,000 | 346,000 | 0.36% | ||
| 27 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 70,000 | 346,000 | 0.36% | ||
| 28 | BlackRock Investment Management, LLC | 61,473 | 304,000 | 0.32% | ||
| 29 | CITADEL ADVISORS LLC | 57,791 | 286,000 | 0.30% | ||
| 30 | D. E. Shaw & Co., Inc. | 56,887 | 282,000 | 0.30% | ||
| 31 | Bank of New York Mellon Corp | 55,915 | 277,000 | 0.29% | ||
| 32 | ROYAL BANK OF CANADA | 49,210 | 244,000 | 0.26% | ||
| 33 | GOLDMAN SACHS GROUP INC | 47,814 | 237,000 | 0.25% | ||
| 34 | RENAISSANCE TECHNOLOGIES LLC | 47,300 | 234,000 | 0.24% | ||
| 35 | GILDER GAGNON HOWE & CO LLC | 45,150 | 223,000 | 0.23% | ||
| 36 | Rhenman & Partners Asset Management AB | 40,000 | 198,000 | 0.21% | ||
| 37 | A.R.T. Advisors, LLC | 38,433 | 190,000 | 0.20% | ||
| 38 | WELLS FARGO & COMPANY/MN | 37,928 | 188,000 | 0.20% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,539 | 186,000 | 0.19% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,700 | 182,000 | 0.19% | Put | |
| 41 | ALPS ADVISORS INC | 34,792 | 172,000 | 0.18% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 28,997 | 144,000 | 0.15% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 27,300 | 135,000 | 0.14% | ||
| 44 | TEACHERS ADVISORS, LLC | 25,268 | 125,000 | 0.13% | ||
| 45 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 22,354 | 111,000 | 0.12% | ||
| 46 | ProShare Advisors LLC | 20,623 | 102,000 | 0.11% | ||
| 47 | SCHONFELD STRATEGIC ADVISORS LLC | 19,670 | 97,000 | 0.10% | ||
| 48 | Swiss National Bank | 19,000 | 94,000 | 0.10% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 18,570 | 92,000 | 0.10% | ||
| 50 | CREDIT SUISSE AG/ | 17,451 | 86,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
