| 1 |
SABBY MANAGEMENT, LLC |
2,686,247 |
9,913,000 |
24.41% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
2,670,300 |
9,853,000 |
24.26% |
|
|
| 3 |
Broadfin Capital, LLC |
1,968,631 |
7,264,000 |
17.88% |
|
|
| 4 |
GREAT POINT PARTNERS LLC |
1,108,593 |
4,091,000 |
10.07% |
|
|
| 5 |
VANGUARD GROUP INC |
975,246 |
3,599,000 |
8.86% |
|
|
| 6 |
Opaleye Management Inc. |
635,000 |
2,343,000 |
5.77% |
|
|
| 7 |
BAKER BROS. ADVISORS LP |
355,348 |
1,311,000 |
3.23% |
|
|
| 8 |
DEUTSCHE BANK AG\ |
145,000 |
534,000 |
1.31% |
|
|
| 9 |
Bank of New York Mellon Corp |
129,134 |
477,000 |
1.17% |
|
|
| 10 |
GEODE CAPITAL MANAGEMENT, LLC |
80,411 |
296,000 |
0.73% |
|
|
| 11 |
BlackRock Fund Advisors |
65,387 |
241,000 |
0.59% |
|
|
| 12 |
Creative Planning |
44,024 |
162,000 |
0.40% |
|
|
| 13 |
Verition Fund Management LLC |
39,175 |
145,000 |
0.36% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
31,830 |
117,000 |
0.29% |
|
|
| 15 |
NORTHERN TRUST CORP |
24,526 |
91,000 |
0.22% |
|
|
| 16 |
GOLDMAN SACHS GROUP INC |
21,360 |
79,000 |
0.19% |
|
|
| 17 |
FIRST NEW YORK SECURITIES LLC /NY |
8,000 |
29,520 |
0.07% |
|
|
| 18 |
MORGAN STANLEY |
3,514 |
13,000 |
0.03% |
|
|
| 19 |
BlackRock Investment Management, LLC |
3,534 |
13,000 |
0.03% |
|
|
| 20 |
FNY Managed Accounts LLC |
3,000 |
11,070 |
0.03% |
|
|
| 21 |
CITIGROUP INC |
2,000 |
7,000 |
0.02% |
|
|
| 22 |
UBS Group AG |
1,785 |
7,000 |
0.02% |
|
|
| 23 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,300 |
4,797 |
0.01% |
|
|
| 24 |
ROYAL BANK OF CANADA |
661 |
3,000 |
0.01% |
|
|
| 25 |
Karp Capital Management Corp |
700 |
3,000 |
0.01% |
|
|
| 26 |
Tower Research Capital LLC (TRC) |
507 |
2,000 |
0.00% |
|
|
| 27 |
INTEGRATED WEALTH MANAGEMENT |
464 |
2,000 |
0.00% |
|
|
| 28 |
BlackRock Japan Co. Ltd |
667 |
2,000 |
0.00% |
|
|
| 29 |
BLACKROCK ADVISORS LLC |
319 |
1,000 |
0.00% |
|
|
| 30 |
BANK OF MONTREAL /CAN/ |
400 |
1,000 |
0.00% |
|
|
| 31 |
North Star Investment Management Corp. |
17 |
0 |
0.00% |
|
|
| 32 |
Kavar Capital Partners, LLC |
10 |
0 |
0.00% |
|
|
| 33 |
SIMPLEX TRADING, LLC |
1 |
0 |
0.00% |
|
|
| 34 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1 |
0 |
0.00% |
|
|
| 35 |
Hudock, Inc. |
6 |
0 |
0.00% |
|
|
| 36 |
Allworth Financial LP |
2 |
0 |
0.00% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
3 |
0 |
0.00% |
|
|
| 38 |
BANK OF AMERICA CORP /DE/ |
72 |
0 |
0.00% |
|
|
