| 1 |
SABBY MANAGEMENT, LLC |
2,693,537 |
8,835,000 |
22.15% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
2,389,700 |
7,838,000 |
19.65% |
|
|
| 3 |
Broadfin Capital, LLC |
1,968,631 |
6,457,000 |
16.19% |
|
|
| 4 |
GREAT POINT PARTNERS LLC |
1,108,593 |
3,636,000 |
9.12% |
|
|
| 5 |
ARMISTICE CAPITAL, LLC |
990,000 |
3,247,000 |
8.14% |
|
|
| 6 |
VANGUARD GROUP INC |
982,713 |
3,223,000 |
8.08% |
|
|
| 7 |
Opaleye Management Inc. |
540,000 |
1,771,000 |
4.44% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
420,000 |
1,378,000 |
3.45% |
|
|
| 9 |
COMMERZBANK AKTIENGESELLSCHAFT /FI |
300,000 |
984,000 |
2.47% |
|
|
| 10 |
Bank of New York Mellon Corp |
129,145 |
424,000 |
1.06% |
|
|
| 11 |
DEUTSCHE BANK AG\ |
92,900 |
304,000 |
0.76% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
90,825 |
297,000 |
0.74% |
|
|
| 13 |
DAFNA Capital Management LLC |
79,509 |
261,000 |
0.65% |
|
|
| 14 |
BlackRock Fund Advisors |
66,464 |
218,000 |
0.55% |
|
|
| 15 |
Nationwide Fund Advisors |
60,000 |
197,000 |
0.49% |
|
|
| 16 |
BAILARD, INC. |
60,000 |
197,000 |
0.49% |
|
|
| 17 |
DIMENSIONAL FUND ADVISORS LP |
40,190 |
132,000 |
0.33% |
|
|
| 18 |
Verition Fund Management LLC |
32,140 |
105,000 |
0.26% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
31,830 |
104,000 |
0.26% |
|
|
| 20 |
NORTHERN TRUST CORP |
28,014 |
92,000 |
0.23% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
25,611 |
84,000 |
0.21% |
|
|
| 22 |
CREDIT SUISSE AG/ |
13,001 |
43,000 |
0.11% |
|
|
| 23 |
UBS Group AG |
6,837 |
22,000 |
0.06% |
|
|
| 24 |
BlackRock Investment Management, LLC |
3,802 |
12,000 |
0.03% |
|
|
| 25 |
BLACKROCK ADVISORS LLC |
1,873 |
6,000 |
0.02% |
|
|
| 26 |
MORGAN STANLEY |
1,800 |
6,000 |
0.02% |
|
|
| 27 |
BlackRock Japan Co. Ltd |
1,271 |
4,000 |
0.01% |
|
|
| 28 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,300 |
4,000 |
0.01% |
|
|
| 29 |
IFP ADVISORS, INC |
706 |
2,000 |
0.01% |
|
|
| 30 |
ROYAL BANK OF CANADA |
476 |
2,000 |
0.01% |
|
|
| 31 |
INTEGRATED WEALTH MANAGEMENT |
464 |
2,000 |
0.01% |
|
|
| 32 |
Tower Research Capital LLC (TRC) |
174 |
1,000 |
0.00% |
|
|
| 33 |
Kavar Capital Partners, LLC |
10 |
0 |
0.00% |
|
|
| 34 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1 |
0 |
0.00% |
|
|
| 35 |
BANK OF MONTREAL /CAN/ |
2 |
0 |
0.00% |
|
|
| 36 |
Hudock, Inc. |
6 |
0 |
0.00% |
|
|
| 37 |
CITIGROUP INC |
1 |
0 |
0.00% |
|
|
| 38 |
Allworth Financial LP |
2 |
0 |
0.00% |
|
|
| 39 |
WELLS FARGO & COMPANY/MN |
17 |
0 |
0.00% |
|
|
| 40 |
BANK OF AMERICA CORP /DE/ |
78 |
0 |
0.00% |
|
|
| 41 |
North Star Investment Management Corp. |
17 |
0 |
0.00% |
|
|
