| 1 |
SABBY MANAGEMENT, LLC |
2,771,109 |
5,681,000 |
22.26% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
2,389,700 |
4,899,000 |
19.20% |
|
|
| 3 |
Broadfin Capital, LLC |
1,968,631 |
4,036,000 |
15.81% |
|
|
| 4 |
ARMISTICE CAPITAL, LLC |
1,170,000 |
2,399,000 |
9.40% |
|
|
| 5 |
GREAT POINT PARTNERS LLC |
1,108,593 |
2,273,000 |
8.91% |
|
|
| 6 |
VANGUARD GROUP INC |
983,413 |
2,016,000 |
7.90% |
|
|
| 7 |
Opaleye Management Inc. |
499,600 |
1,024,000 |
4.01% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
420,000 |
861,000 |
3.37% |
|
|
| 9 |
COMMERZBANK AKTIENGESELLSCHAFT /FI |
300,000 |
615,000 |
2.41% |
|
|
| 10 |
Bank of New York Mellon Corp |
129,158 |
265,000 |
1.04% |
|
|
| 11 |
SCOTIA CAPITAL INC. |
106,206 |
218,000 |
0.85% |
|
|
| 12 |
DEUTSCHE BANK AG\ |
92,900 |
190,000 |
0.74% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
90,732 |
186,000 |
0.73% |
|
|
| 14 |
DAFNA Capital Management LLC |
79,509 |
163,000 |
0.64% |
|
|
| 15 |
BlackRock Fund Advisors |
61,768 |
127,000 |
0.50% |
|
|
| 16 |
Nationwide Fund Advisors |
60,000 |
123,000 |
0.48% |
|
|
| 17 |
DIMENSIONAL FUND ADVISORS LP |
40,190 |
82,000 |
0.32% |
|
|
| 18 |
Verition Fund Management LLC |
32,140 |
66,000 |
0.26% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
31,830 |
65,000 |
0.25% |
|
|
| 20 |
NORTHERN TRUST CORP |
29,904 |
61,000 |
0.24% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
26,266 |
54,000 |
0.21% |
|
|
| 22 |
CREDIT SUISSE AG/ |
19,000 |
39,000 |
0.15% |
|
|
| 23 |
CITADEL ADVISORS LLC |
14,407 |
30,000 |
0.12% |
|
|
| 24 |
Virtu KCG Holdings LLC |
10,373 |
21,000 |
0.08% |
|
|
| 25 |
BlackRock Investment Management, LLC |
3,802 |
8,000 |
0.03% |
|
|
| 26 |
MORGAN STANLEY |
1,918 |
4,000 |
0.02% |
|
|
| 27 |
BLACKROCK ADVISORS LLC |
1,873 |
4,000 |
0.02% |
|
|
| 28 |
Tower Research Capital LLC (TRC) |
1,538 |
3,000 |
0.01% |
|
|
| 29 |
BlackRock Japan Co. Ltd |
1,234 |
3,000 |
0.01% |
|
|
| 30 |
AMERICAN INTERNATIONAL GROUP, INC. |
1,300 |
3,000 |
0.01% |
|
|
| 31 |
IFP ADVISORS, INC |
706 |
1,000 |
0.00% |
|
|
| 32 |
ROYAL BANK OF CANADA |
476 |
1,000 |
0.00% |
|
|
| 33 |
INTEGRATED WEALTH MANAGEMENT |
464 |
1,000 |
0.00% |
|
|
| 34 |
CITIGROUP INC |
1 |
0 |
0.00% |
|
|
| 35 |
Hudock, Inc. |
6 |
0 |
0.00% |
|
|
| 36 |
Allworth Financial LP |
2 |
0 |
0.00% |
|
|
| 37 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1 |
0 |
0.00% |
|
|
| 38 |
WELLS FARGO & COMPANY/MN |
17 |
0 |
0.00% |
|
|
| 39 |
BANK OF AMERICA CORP /DE/ |
78 |
0 |
0.00% |
|
|
| 40 |
UBS Group AG |
16 |
0 |
0.00% |
|
|
| 41 |
North Star Investment Management Corp. |
17 |
0 |
0.00% |
|
|
| 42 |
BANK OF MONTREAL /CAN/ |
2 |
0 |
0.00% |
|
|
