| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 2,613,199 | 43,484,000 | 36.10% | ||
| 2 | FMR LLC | 1,702,282 | 28,326,000 | 23.52% | ||
| 3 | AWM Investment Company, Inc. | 825,000 | 13,728,000 | 11.40% | ||
| 4 | BVF INC/IL | 753,935 | 12,545,000 | 10.42% | ||
| 5 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 439,524 | 7,287,000 | 6.05% | ||
| 6 | EcoR1 Capital, LLC | 207,000 | 3,444,000 | 2.86% | ||
| 7 | VANGUARD GROUP INC | 127,677 | 2,125,000 | 1.76% | ||
| 8 | JPMORGAN CHASE & CO | 100,600 | 1,674,000 | 1.39% | ||
| 9 | Informed Momentum Co LLC | 78,477 | 1,306,000 | 1.08% | ||
| 10 | NORTHERN TRUST CORP | 60,418 | 1,006,000 | 0.84% | ||
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 43,409 | 722,000 | 0.60% | ||
| 12 | A.R.T. Advisors, LLC | 41,150 | 684,000 | 0.57% | ||
| 13 | GOLDMAN SACHS GROUP INC | 31,561 | 525,000 | 0.44% | ||
| 14 | STATE STREET CORP | 29,786 | 496,000 | 0.41% | ||
| 15 | CITADEL ADVISORS LLC | 27,089 | 451,000 | 0.37% | ||
| 16 | MORGAN STANLEY | 24,408 | 406,000 | 0.34% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,687 | 344,000 | 0.29% | ||
| 18 | Bank of New York Mellon Corp | 19,106 | 318,000 | 0.26% | ||
| 19 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 14,285 | 237,000 | 0.20% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 13,816 | 230,000 | 0.19% | ||
| 21 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,654 | 228,000 | 0.19% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 11,627 | 193,000 | 0.16% | ||
| 23 | Virtu KCG Holdings LLC | 11,295 | 188,000 | 0.16% | ||
| 24 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,400 | 173,000 | 0.14% | ||
| 25 | TEACHERS ADVISORS, LLC | 5,047 | 84,000 | 0.07% | ||
| 26 | Nationwide Fund Advisors | 4,078 | 68,000 | 0.06% | ||
| 27 | AMERICAN INTERNATIONAL GROUP, INC. | 3,528 | 58,706 | 0.05% | ||
| 28 | Tower Research Capital LLC (TRC) | 2,992 | 50,000 | 0.04% | ||
| 29 | STRS OHIO | 1,900 | 32,000 | 0.03% | ||
| 30 | CITIGROUP INC | 1,059 | 18,000 | 0.01% | ||
| 31 | UBS Group AG | 566 | 9,000 | 0.01% | ||
| 32 | BARCLAYS PLC | 456 | 7,000 | 0.01% | ||
| 33 | ROYAL BANK OF CANADA | 18 | 0 | 0.00% | ||
| 34 | DEUTSCHE BANK AG\ | 2 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
