| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,400,000 | 22,542,000 | 16.51% | ||
| 2 | FMR LLC | 2,526,273 | 16,749,000 | 12.27% | ||
| 3 | BVF INC/IL | 2,089,014 | 13,850,000 | 10.14% | ||
| 4 | Cormorant Asset Management, LP | 1,735,000 | 11,503,000 | 8.42% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 1,575,000 | 10,442,000 | 7.65% | ||
| 6 | AWM Investment Company, Inc. | 1,203,821 | 7,981,000 | 5.84% | ||
| 7 | DAFNA Capital Management LLC | 787,373 | 5,220,000 | 3.82% | ||
| 8 | BAKER BROS. ADVISORS LP | 637,597 | 4,227,000 | 3.10% | ||
| 9 | BlackRock Fund Advisors | 630,686 | 4,181,000 | 3.06% | ||
| 10 | VANGUARD GROUP INC | 589,265 | 3,907,000 | 2.86% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 476,918 | 3,162,000 | 2.32% | ||
| 12 | Point72 Asset Management, L.P. | 475,000 | 3,149,000 | 2.31% | ||
| 13 | MITRA CAPITAL LLC | 402,849 | 2,671,000 | 1.96% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 383,040 | 2,540,000 | 1.86% | ||
| 15 | Alyeska Investment Group, L.P. | 375,000 | 2,486,000 | 1.82% | ||
| 16 | BOXER CAPITAL, LLC | 315,025 | 2,089,000 | 1.53% | ||
| 17 | BALYASNY ASSET MANAGEMENT L.P. | 279,156 | 1,851,000 | 1.36% | ||
| 18 | JPMORGAN CHASE & CO | 188,800 | 1,251,000 | 0.92% | ||
| 19 | STATE STREET CORP | 187,856 | 1,245,000 | 0.91% | ||
| 20 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 185,000 | 1,227,000 | 0.90% | ||
| 21 | PUTNAM INVESTMENTS LLC | 144,249 | 956,000 | 0.70% | ||
| 22 | NORTHERN TRUST CORP | 136,495 | 905,000 | 0.66% | ||
| 23 | HANDELSBANKEN FONDER AB | 133,000 | 882,000 | 0.65% | ||
| 24 | MARSHALL WACE, LLP | 128,747 | 854,000 | 0.63% | ||
| 25 | Polar Capital LLP | 110,000 | 729,000 | 0.53% | ||
| 26 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 108,314 | 718,000 | 0.53% | ||
| 27 | DIMENSIONAL FUND ADVISORS LP | 107,751 | 714,000 | 0.52% | ||
| 28 | Ghost Tree Capital, LLC | 101,188 | 671,000 | 0.49% | ||
| 29 | OXFORD ASSET MANAGEMENT LLP | 97,782 | 648,000 | 0.47% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 84,010 | 556,000 | 0.41% | ||
| 31 | MORGAN STANLEY | 71,651 | 475,000 | 0.35% | ||
| 32 | A.R.T. Advisors, LLC | 68,066 | 451,000 | 0.33% | ||
| 33 | PRICE T ROWE ASSOCIATES INC /MD/ | 50,156 | 333,000 | 0.24% | ||
| 34 | GOLDMAN SACHS GROUP INC | 49,444 | 328,000 | 0.24% | ||
| 35 | Bank of New York Mellon Corp | 48,804 | 323,000 | 0.24% | ||
| 36 | BlackRock Investment Management, LLC | 46,826 | 310,000 | 0.23% | ||
| 37 | Invesco Ltd. | 46,421 | 308,000 | 0.23% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 38,634 | 256,000 | 0.19% | ||
| 39 | Nationwide Fund Advisors | 38,533 | 255,000 | 0.19% | ||
| 40 | D. E. Shaw & Co., Inc. | 36,926 | 245,000 | 0.18% | ||
| 41 | JANE STREET GROUP, LLC | 35,224 | 234,000 | 0.17% | ||
| 42 | GRATICULE ASIA MACRO ADVISORS LLC | 33,777 | 224,000 | 0.16% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 33,189 | 221,000 | 0.16% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,501 | 189,000 | 0.14% | ||
| 45 | HAMILTON LANE ADVISORS LLC | 27,580 | 183,000 | 0.13% | ||
| 46 | ELLINGTON MANAGEMENT GROUP LLC | 24,900 | 165,000 | 0.12% | ||
| 47 | CREDIT SUISSE AG/ | 24,756 | 164,000 | 0.12% | ||
| 48 | ALPS ADVISORS INC | 24,595 | 163,000 | 0.12% | ||
| 49 | Quantitative Systematic Strategies LLC | 24,301 | 157,000 | 0.11% | ||
| 50 | TUDOR INVESTMENT CORP ET AL | 23,393 | 155,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
