| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,274,473 | 36,052,000 | 22.73% | ||
| 2 | BVF INC/IL | 2,375,933 | 26,159,000 | 16.49% | ||
| 3 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,432,004 | 15,766,000 | 9.94% | ||
| 4 | AWM Investment Company, Inc. | 795,624 | 8,760,000 | 5.52% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 758,455 | 8,351,000 | 5.27% | ||
| 6 | Point72 Asset Management, L.P. | 594,535 | 6,546,000 | 4.13% | ||
| 7 | JPMORGAN CHASE & CO | 398,793 | 4,390,000 | 2.77% | ||
| 8 | VANGUARD GROUP INC | 379,959 | 4,184,000 | 2.64% | ||
| 9 | ORBIMED ADVISORS LLC | 361,500 | 3,980,000 | 2.51% | ||
| 10 | BlackRock Fund Advisors | 343,115 | 3,778,000 | 2.38% | ||
| 11 | ALPS ADVISORS INC | 34,204 | 3,766,000 | 2.37% | ||
| 12 | RA CAPITAL MANAGEMENT, L.P. | 321,161 | 3,536,000 | 2.23% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 301,421 | 3,319,000 | 2.09% | ||
| 14 | Ghost Tree Capital, LLC | 250,000 | 2,753,000 | 1.74% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 200,000 | 2,202,000 | 1.39% | ||
| 16 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 198,848 | 2,189,000 | 1.38% | ||
| 17 | BAKER BROS. ADVISORS LP | 187,597 | 2,065,000 | 1.30% | ||
| 18 | HAMILTON LANE ADVISORS LLC | 170,935 | 1,882,000 | 1.19% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 144,284 | 1,589,000 | 1.00% | ||
| 20 | PUTNAM INVESTMENTS LLC | 140,000 | 1,541,000 | 0.97% | ||
| 21 | NORTHERN TRUST CORP | 132,349 | 1,457,000 | 0.92% | ||
| 22 | STATE STREET CORP | 121,865 | 1,343,000 | 0.85% | ||
| 23 | D. E. Shaw & Co., Inc. | 120,923 | 1,331,000 | 0.84% | ||
| 24 | Invesco Ltd. | 109,597 | 1,207,000 | 0.76% | ||
| 25 | GRATICULE ASIA MACRO ADVISORS LLC | 105,000 | 1,155,000 | 0.73% | ||
| 26 | HARBOURVEST PARTNERS LLC | 85,217 | 938,000 | 0.59% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 74,837 | 823,000 | 0.52% | ||
| 28 | DAFNA Capital Management LLC | 70,885 | 780,000 | 0.49% | ||
| 29 | Nationwide Fund Advisors | 56,058 | 617,000 | 0.39% | ||
| 30 | BlackRock Investment Management, LLC | 45,792 | 504,000 | 0.32% | ||
| 31 | Alyeska Investment Group, L.P. | 45,631 | 502,000 | 0.32% | ||
| 32 | Atika Capital Management LLC | 45,000 | 495,000 | 0.31% | ||
| 33 | Bank of New York Mellon Corp | 40,153 | 442,000 | 0.28% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 36,869 | 406,000 | 0.26% | ||
| 35 | ADAMS STREET PARTNERS LLC | 35,073 | 386,000 | 0.24% | ||
| 36 | ELLINGTON MANAGEMENT GROUP LLC | 27,911 | 307,000 | 0.19% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,449 | 303,000 | 0.19% | ||
| 38 | GOLDMAN SACHS GROUP INC | 26,881 | 296,000 | 0.19% | ||
| 39 | GENERAL MOTORS INVESTMENT MANAGEMENT CORP | 26,023 | 287,000 | 0.18% | ||
| 40 | TEACHERS ADVISORS, LLC | 19,340 | 213,000 | 0.13% | ||
| 41 | Polar Capital LLP | 19,011 | 209,000 | 0.13% | ||
| 42 | PRUDENTIAL FINANCIAL INC | 18,873 | 208,000 | 0.13% | ||
| 43 | STRS OHIO | 18,933 | 208,000 | 0.13% | ||
| 44 | CREDIT SUISSE AG/ | 14,670 | 162,000 | 0.10% | ||
| 45 | GLENMEDE TRUST CO NA | 12,546 | 138,000 | 0.09% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 12,100 | 133,000 | 0.08% | ||
| 47 | RHUMBLINE ADVISERS | 10,881 | 120,000 | 0.08% | ||
| 48 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10,100 | 111,000 | 0.07% | ||
| 49 | Kemnay Advisory Services Inc. | 9,736 | 107,000 | 0.07% | ||
| 50 | MORGAN STANLEY | 8,882 | 98,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
