| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,879,582 | 33,720,000 | 24.49% | ||
| 2 | NEA Management Company, LLC | 2,613,199 | 30,601,000 | 22.23% | ||
| 3 | BVF INC/IL | 1,577,435 | 18,472,000 | 13.42% | ||
| 4 | AWM Investment Company, Inc. | 872,000 | 10,211,000 | 7.42% | ||
| 5 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 423,001 | 4,953,000 | 3.60% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 4,684,000 | 3.40% | ||
| 7 | Point72 Asset Management, L.P. | 365,000 | 4,274,000 | 3.10% | ||
| 8 | Ghost Tree Capital, LLC | 300,000 | 3,513,000 | 2.55% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 267,147 | 3,128,000 | 2.27% | ||
| 10 | JPMORGAN CHASE & CO | 261,160 | 3,058,000 | 2.22% | ||
| 11 | VANGUARD GROUP INC | 252,772 | 2,960,000 | 2.15% | ||
| 12 | BAKER BROS. ADVISORS LP | 187,597 | 2,197,000 | 1.60% | ||
| 13 | BlackRock Fund Advisors | 180,809 | 2,117,000 | 1.54% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 176,492 | 2,067,000 | 1.50% | ||
| 15 | GOLDMAN SACHS GROUP INC | 162,261 | 1,900,000 | 1.38% | ||
| 16 | PUTNAM INVESTMENTS LLC | 140,000 | 1,639,000 | 1.19% | ||
| 17 | BLACKROCK ADVISORS LLC | 98,077 | 1,148,000 | 0.83% | ||
| 18 | NORTHERN TRUST CORP | 74,333 | 870,000 | 0.63% | ||
| 19 | GSA CAPITAL PARTNERS LLP | 68,877 | 807,000 | 0.59% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 67,441 | 789,000 | 0.57% | ||
| 21 | STATE STREET CORP | 60,126 | 703,000 | 0.51% | ||
| 22 | Alyeska Investment Group, L.P. | 36,441 | 427,000 | 0.31% | ||
| 23 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 35,315 | 414,000 | 0.30% | ||
| 24 | BANK OF MONTREAL /CAN/ | 34,733 | 407,000 | 0.30% | ||
| 25 | Bank of New York Mellon Corp | 32,556 | 381,000 | 0.28% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 32,332 | 379,000 | 0.28% | ||
| 27 | Polar Capital LLP | 22,238 | 260,000 | 0.19% | ||
| 28 | BlackRock Investment Management, LLC | 19,349 | 227,000 | 0.16% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 16,801 | 197,000 | 0.14% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,466 | 170,000 | 0.12% | ||
| 31 | HAMILTON LANE ADVISORS LLC | 13,537 | 159,000 | 0.12% | ||
| 32 | BESSEMER GROUP INC | 12,980 | 152,000 | 0.11% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,000 | 141,000 | 0.10% | ||
| 34 | TEACHERS ADVISORS, LLC | 8,546 | 100,000 | 0.07% | ||
| 35 | BlackRock Group LTD | 8,122 | 95,000 | 0.07% | ||
| 36 | MORGAN STANLEY | 6,226 | 73,000 | 0.05% | ||
| 37 | Nationwide Fund Advisors | 4,854 | 57,000 | 0.04% | ||
| 38 | TRAVELERS COMPANIES, INC. | 4,057 | 48,000 | 0.03% | ||
| 39 | AMERICAN INTERNATIONAL GROUP, INC. | 3,528 | 41,313 | 0.03% | ||
| 40 | ACADIAN ASSET MANAGEMENT LLC | 3,071 | 36,000 | 0.03% | ||
| 41 | WELLS FARGO & COMPANY/MN | 2,119 | 25,000 | 0.02% | ||
| 42 | STRS OHIO | 1,900 | 22,000 | 0.02% | ||
| 43 | TURNER INVESTMENTS LLC | 1,500 | 18,000 | 0.01% | ||
| 44 | BlackRock Japan Co. Ltd | 1,544 | 18,000 | 0.01% | ||
| 45 | Cubist Systematic Strategies, LLC | 1,200 | 14,000 | 0.01% | ||
| 46 | CITIGROUP INC | 357 | 4,000 | 0.00% | ||
| 47 | BlackRock Finance, Inc. | 203 | 2,000 | 0.00% | ||
| 48 | BARCLAYS PLC | 199 | 2,000 | 0.00% | ||
| 49 | BNP PARIBAS FINANCIAL MARKETS | 144 | 1,686 | 0.00% | ||
| 50 | DEUTSCHE BANK AG\ | 1 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
