| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,179,473 | 45,097,000 | 19.97% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,400,000 | 36,686,000 | 16.25% | ||
| 3 | Cormorant Asset Management, LP | 1,754,795 | 18,934,000 | 8.38% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,575,000 | 16,994,000 | 7.53% | ||
| 5 | AWM Investment Company, Inc. | 1,177,864 | 12,709,000 | 5.63% | ||
| 6 | BlackRock Fund Advisors | 1,050,353 | 11,333,000 | 5.02% | ||
| 7 | VANGUARD GROUP INC | 770,488 | 8,314,000 | 3.68% | ||
| 8 | BVF INC/IL | 761,079 | 8,212,000 | 3.64% | ||
| 9 | DAFNA Capital Management LLC | 660,188 | 7,123,000 | 3.15% | ||
| 10 | BAKER BROS. ADVISORS LP | 637,597 | 6,880,000 | 3.05% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 570,657 | 6,157,000 | 2.73% | ||
| 12 | STATE STREET CORP | 344,027 | 3,710,000 | 1.64% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 336,463 | 3,630,000 | 1.61% | ||
| 14 | JPMORGAN CHASE & CO | 319,100 | 3,443,000 | 1.52% | ||
| 15 | OXFORD ASSET MANAGEMENT LLP | 314,326 | 3,392,000 | 1.50% | ||
| 16 | BALYASNY ASSET MANAGEMENT L.P. | 301,086 | 3,249,000 | 1.44% | ||
| 17 | Polar Capital LLP | 300,000 | 3,237,000 | 1.43% | ||
| 18 | NORTHERN TRUST CORP | 295,225 | 3,186,000 | 1.41% | ||
| 19 | Century Capital Management, LLC | 197,225 | 2,128,000 | 0.94% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 153,760 | 1,659,000 | 0.73% | ||
| 21 | HANDELSBANKEN FONDER AB | 153,000 | 1,651,000 | 0.73% | ||
| 22 | PUTNAM INVESTMENTS LLC | 144,249 | 1,557,000 | 0.69% | ||
| 23 | MARSHALL WACE, LLP | 118,955 | 1,284,000 | 0.57% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 104,484 | 1,127,000 | 0.50% | ||
| 25 | BlackRock Investment Management, LLC | 101,185 | 1,092,000 | 0.48% | ||
| 26 | Bank of New York Mellon Corp | 87,719 | 947,000 | 0.42% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 80,791 | 872,000 | 0.39% | ||
| 28 | ClariVest Asset Management LLC | 68,036 | 734,000 | 0.33% | ||
| 29 | DIMENSIONAL FUND ADVISORS LP | 68,016 | 734,000 | 0.33% | ||
| 30 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 60,350 | 651,000 | 0.29% | ||
| 31 | GOLDMAN SACHS GROUP INC | 58,950 | 636,000 | 0.28% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,134 | 595,000 | 0.26% | ||
| 33 | MITRA CAPITAL LLC | 55,027 | 594,000 | 0.26% | ||
| 34 | Point72 Asset Management, L.P. | 55,074 | 594,000 | 0.26% | ||
| 35 | PRICE T ROWE ASSOCIATES INC /MD/ | 50,156 | 541,000 | 0.24% | ||
| 36 | DEUTSCHE BANK AG\ | 47,460 | 510,000 | 0.23% | ||
| 37 | Nationwide Fund Advisors | 46,537 | 502,000 | 0.22% | ||
| 38 | TEACHERS ADVISORS, LLC | 41,690 | 450,000 | 0.20% | ||
| 39 | ALPS ADVISORS INC | 40,515 | 437,000 | 0.19% | ||
| 40 | DEERE & CO | 38,100 | 411,000 | 0.18% | ||
| 41 | Spark Investment Management LLC | 28,800 | 310,000 | 0.14% | ||
| 42 | CREDIT SUISSE AG/ | 25,805 | 278,000 | 0.12% | ||
| 43 | HAMILTON LANE ADVISORS LLC | 27,580 | 277,000 | 0.12% | ||
| 44 | ProShare Advisors LLC | 24,686 | 266,000 | 0.12% | ||
| 45 | VIRTUS ETF ADVISERS LLC | 24,463 | 264,000 | 0.12% | ||
| 46 | RHUMBLINE ADVISERS | 23,214 | 250,000 | 0.11% | ||
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 21,143 | 228,000 | 0.10% | ||
| 48 | STRS OHIO | 18,933 | 204,000 | 0.09% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,787 | 203,000 | 0.09% | ||
| 50 | CITADEL ADVISORS LLC | 17,574 | 190,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
