| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,274,473 | 59,268,000 | 20.91% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,150,000 | 38,915,000 | 13.73% | ||
| 3 | BVF INC/IL | 2,061,325 | 37,310,000 | 13.17% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 873,436 | 15,809,000 | 5.58% | ||
| 5 | AWM Investment Company, Inc. | 795,624 | 14,401,000 | 5.08% | ||
| 6 | Cormorant Asset Management, LP | 623,409 | 11,284,000 | 3.98% | ||
| 7 | BlackRock Fund Advisors | 613,466 | 11,104,000 | 3.92% | ||
| 8 | ORBIMED ADVISORS LLC | 487,400 | 8,822,000 | 3.11% | ||
| 9 | VANGUARD GROUP INC | 421,103 | 7,622,000 | 2.69% | ||
| 10 | RA CAPITAL MANAGEMENT, L.P. | 321,161 | 5,813,000 | 2.05% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 308,482 | 5,584,000 | 1.97% | ||
| 12 | Ghost Tree Capital, LLC | 275,000 | 4,978,000 | 1.76% | ||
| 13 | BOXER CAPITAL, LLC | 250,270 | 4,530,000 | 1.60% | ||
| 14 | DRIEHAUS CAPITAL MANAGEMENT LLC | 242,905 | 4,397,000 | 1.55% | ||
| 15 | JPMORGAN CHASE & CO | 203,629 | 3,686,000 | 1.30% | ||
| 16 | D. E. Shaw & Co., Inc. | 203,462 | 3,683,000 | 1.30% | ||
| 17 | PERCEPTIVE ADVISORS LLC | 200,000 | 3,620,000 | 1.28% | ||
| 18 | DAFNA Capital Management LLC | 193,224 | 3,497,000 | 1.23% | ||
| 19 | BAKER BROS. ADVISORS LP | 187,597 | 3,396,000 | 1.20% | ||
| 20 | STATE STREET CORP | 151,024 | 2,735,000 | 0.97% | ||
| 21 | PUTNAM INVESTMENTS LLC | 140,000 | 2,534,000 | 0.89% | ||
| 22 | NORTHERN TRUST CORP | 136,686 | 2,474,000 | 0.87% | ||
| 23 | Candriam S.C.A. | 133,000 | 2,407,000 | 0.85% | ||
| 24 | SPHERA FUNDS MANAGEMENT LTD. | 120,000 | 2,172,000 | 0.77% | ||
| 25 | BALYASNY ASSET MANAGEMENT L.P. | 115,800 | 2,096,000 | 0.74% | ||
| 26 | Invesco Ltd. | 108,761 | 1,969,000 | 0.69% | ||
| 27 | A.R.T. Advisors, LLC | 77,966 | 1,411,000 | 0.50% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 74,951 | 1,356,000 | 0.48% | ||
| 29 | DIMENSIONAL FUND ADVISORS LP | 73,607 | 1,332,000 | 0.47% | ||
| 30 | Opaleye Management Inc. | 58,500 | 1,059,000 | 0.37% | ||
| 31 | PRICE T ROWE ASSOCIATES INC /MD/ | 50,156 | 908,000 | 0.32% | ||
| 32 | BlackRock Investment Management, LLC | 45,920 | 831,000 | 0.29% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 45,463 | 823,000 | 0.29% | ||
| 34 | Bank of New York Mellon Corp | 42,000 | 760,000 | 0.27% | ||
| 35 | Nationwide Fund Advisors | 40,033 | 725,000 | 0.26% | ||
| 36 | Atika Capital Management LLC | 40,000 | 724,000 | 0.26% | ||
| 37 | GRATICULE ASIA MACRO ADVISORS LLC | 39,800 | 721,000 | 0.25% | ||
| 38 | HANDELSBANKEN FONDER AB | 38,000 | 688,000 | 0.24% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,577 | 590,000 | 0.21% | ||
| 40 | ALPS ADVISORS INC | 28,810 | 521,000 | 0.18% | ||
| 41 | HAMILTON LANE ADVISORS LLC | 27,580 | 499,000 | 0.18% | ||
| 42 | ROWLANDMILLER & PARTNERS.ADV | 4,487 | 457,000 | 0.16% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,614 | 446,000 | 0.16% | ||
| 44 | CITADEL ADVISORS LLC | 24,495 | 443,000 | 0.16% | ||
| 45 | Polar Capital LLP | 22,608 | 409,000 | 0.14% | ||
| 46 | TEACHERS ADVISORS, LLC | 21,264 | 385,000 | 0.14% | ||
| 47 | NEXTHERA CAPITAL LP | 20,720 | 375,000 | 0.13% | ||
| 48 | ProShare Advisors LLC | 19,516 | 353,000 | 0.12% | ||
| 49 | STRS OHIO | 18,933 | 342,000 | 0.12% | ||
| 50 | Quantitative Systematic Strategies LLC | 17,019 | 306,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
