| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,274,473 | 47,152,000 | 24.47% | ||
| 2 | NEA Management Company, LLC | 2,613,199 | 37,630,000 | 19.53% | ||
| 3 | BVF INC/IL | 1,604,615 | 23,106,000 | 11.99% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,025,000 | 14,760,000 | 7.66% | ||
| 5 | AWM Investment Company, Inc. | 872,000 | 12,557,000 | 6.52% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 763,424 | 10,993,000 | 5.71% | ||
| 7 | Point72 Asset Management, L.P. | 444,842 | 6,406,000 | 3.33% | ||
| 8 | BlackRock Fund Advisors | 345,957 | 4,982,000 | 2.59% | ||
| 9 | Ghost Tree Capital, LLC | 289,200 | 4,164,000 | 2.16% | ||
| 10 | VANGUARD GROUP INC | 283,284 | 4,079,000 | 2.12% | ||
| 11 | JPMORGAN CHASE & CO | 240,400 | 3,462,000 | 1.80% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 222,294 | 3,201,000 | 1.66% | ||
| 13 | BAKER BROS. ADVISORS LP | 187,597 | 2,701,000 | 1.40% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 150,000 | 2,160,000 | 1.12% | ||
| 15 | PUTNAM INVESTMENTS LLC | 140,000 | 2,016,000 | 1.05% | ||
| 16 | STATE STREET CORP | 119,841 | 1,726,000 | 0.90% | ||
| 17 | Allianz Asset Management GmbH | 91,231 | 1,314,000 | 0.68% | ||
| 18 | BLACKROCK ADVISORS LLC | 90,531 | 1,304,000 | 0.68% | ||
| 19 | NORTHERN TRUST CORP | 78,195 | 1,126,000 | 0.58% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 74,214 | 1,068,000 | 0.55% | ||
| 21 | TREDJE AP-FONDEN | 22,000 | 848,000 | 0.44% | ||
| 22 | Bank of New York Mellon Corp | 50,784 | 731,000 | 0.38% | ||
| 23 | BlackRock Investment Management, LLC | 46,560 | 670,000 | 0.35% | ||
| 24 | Alyeska Investment Group, L.P. | 37,041 | 533,000 | 0.28% | ||
| 25 | ROWLANDMILLER & PARTNERS.ADV | 4,358 | 466,000 | 0.24% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,118 | 377,000 | 0.20% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 26,189 | 377,000 | 0.20% | ||
| 28 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,227 | 349,000 | 0.18% | ||
| 29 | Polar Capital LLP | 22,238 | 320,000 | 0.17% | ||
| 30 | ALPS ADVISORS INC | 21,678 | 312,000 | 0.16% | ||
| 31 | TEACHERS ADVISORS, LLC | 19,340 | 278,000 | 0.14% | ||
| 32 | TFS CAPITAL LLC | 14,889 | 214,000 | 0.11% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 11,400 | 164,000 | 0.09% | ||
| 34 | RHUMBLINE ADVISERS | 10,285 | 148,000 | 0.08% | ||
| 35 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10,100 | 145,000 | 0.08% | ||
| 36 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,866 | 127,000 | 0.07% | ||
| 37 | Nationwide Fund Advisors | 8,533 | 123,000 | 0.06% | ||
| 38 | BANK OF MONTREAL /CAN/ | 8,018 | 115,000 | 0.06% | ||
| 39 | AMERICAN INTERNATIONAL GROUP, INC. | 7,773 | 111,931 | 0.06% | ||
| 40 | DEUTSCHE BANK AG\ | 7,087 | 100,000 | 0.05% | ||
| 41 | MORGAN STANLEY | 3,505 | 50,000 | 0.03% | ||
| 42 | Tower Research Capital LLC (TRC) | 3,073 | 44,000 | 0.02% | ||
| 43 | COLONY GROUP LLC | 2,173 | 31,000 | 0.02% | ||
| 44 | UBS Group AG | 1,995 | 29,000 | 0.02% | ||
| 45 | STRS OHIO | 1,900 | 27,000 | 0.01% | ||
| 46 | BNP PARIBAS FINANCIAL MARKETS | 1,104 | 15,898 | 0.01% | ||
| 47 | ROYAL BANK OF CANADA | 995 | 14,000 | 0.01% | ||
| 48 | WELLS FARGO & COMPANY/MN | 664 | 10,000 | 0.01% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 431 | 6,000 | 0.00% | ||
| 50 | Invesco Ltd. | 334 | 5,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
