| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Crestline Management, LP | 25,948,799 | 1,055,857,000 | 46.97% | ||
| 2 | FMR LLC | 7,117,424 | 289,608,000 | 12.88% | ||
| 3 | VANGUARD GROUP INC | 4,377,245 | 178,110,000 | 7.92% | ||
| 4 | Capital World Investors | 3,757,501 | 152,893,000 | 6.80% | ||
| 5 | Omega Fund Management, LLC | 1,329,512 | 54,098,000 | 2.41% | ||
| 6 | BB BIOTECH AG | 1,305,000 | 53,100,000 | 2.36% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,084,459 | 44,127,000 | 1.96% | ||
| 8 | Temasek Holdings (Private) Ltd | 915,750 | 37,262,000 | 1.66% | ||
| 9 | STATE STREET CORP | 858,512 | 34,932,000 | 1.55% | ||
| 10 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 682,200 | 27,759,000 | 1.23% | Put | |
| 11 | GRATICULE ASIA MACRO ADVISORS LLC | 435,205 | 17,708,000 | 0.79% | ||
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 392,708 | 15,979,000 | 0.71% | ||
| 13 | ArrowMark Colorado Holdings LLC | 383,339 | 15,598,000 | 0.69% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 341,116 | 13,880,000 | 0.62% | ||
| 15 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 270,651 | 11,012,000 | 0.49% | ||
| 16 | MORGAN STANLEY | 267,833 | 10,897,000 | 0.48% | ||
| 17 | LORD, ABBETT & CO. LLC | 267,098 | 10,868,000 | 0.48% | ||
| 18 | NORGES BANK | 256,921 | 10,454,000 | 0.47% | ||
| 19 | Artal Group S.A. | 235,000 | 9,562,000 | 0.43% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 212,100 | 8,630,000 | 0.38% | Call | |
| 21 | BAMCO INC /NY/ | 200,000 | 8,138,000 | 0.36% | ||
| 22 | Rock Springs Capital Management LP | 197,001 | 8,016,000 | 0.36% | ||
| 23 | Tekla Capital Management LLC | 182,000 | 7,406,000 | 0.33% | ||
| 24 | FRED ALGER MANAGEMENT, LLC | 171,887 | 6,994,000 | 0.31% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,440 | 6,569,000 | 0.29% | ||
| 26 | JPMORGAN CHASE & CO | 153,395 | 6,242,000 | 0.28% | ||
| 27 | BlackRock Fund Advisors | 146,747 | 5,971,000 | 0.27% | ||
| 28 | GOLDMAN SACHS GROUP INC | 140,786 | 5,729,000 | 0.25% | ||
| 29 | MARSICO CAPITAL MANAGEMENT LLC | 133,979 | 5,451,000 | 0.24% | ||
| 30 | Zurcher Kantonalbank (Zurich Cantonalbank) | 123,361 | 5,020,000 | 0.22% | ||
| 31 | NORTHERN TRUST CORP | 117,104 | 4,765,000 | 0.21% | ||
| 32 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 109,598 | 4,460,000 | 0.20% | ||
| 33 | AMERIPRISE FINANCIAL INC | 105,680 | 4,300,000 | 0.19% | ||
| 34 | Bank of New York Mellon Corp | 103,130 | 4,195,000 | 0.19% | ||
| 35 | GRATICULE ASIA MACRO ADVISORS LLC | 100,000 | 4,069,000 | 0.18% | Call | |
| 36 | CITIGROUP INC | 98,800 | 4,020,000 | 0.18% | Put | |
| 37 | PRICE T ROWE ASSOCIATES INC /MD/ | 97,806 | 3,980,000 | 0.18% | ||
| 38 | CITIGROUP INC | 92,050 | 3,745,000 | 0.17% | ||
| 39 | HSBC HOLDINGS PLC | 91,070 | 3,706,000 | 0.16% | ||
| 40 | US BANCORP \DE\ | 87,100 | 3,544,000 | 0.16% | ||
| 41 | UBS Group AG | 83,840 | 3,411,000 | 0.15% | ||
| 42 | BAKER BROS. ADVISORS LP | 80,000 | 3,255,000 | 0.14% | ||
| 43 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 78,340 | 3,188,000 | 0.14% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 74,007 | 3,011,000 | 0.13% | ||
| 45 | PFM Health Sciences, LP | 73,631 | 2,996,000 | 0.13% | ||
| 46 | TURNER INVESTMENTS LLC | 69,680 | 2,835,000 | 0.13% | ||
| 47 | SUFFOLK CAPITAL MANAGEMENT LLC | 69,298 | 2,820,000 | 0.13% | ||
| 48 | Sculptor Capital LP | 58,500 | 2,380,000 | 0.11% | Put | |
| 49 | Sculptor Capital LP | 58,500 | 2,380,000 | 0.11% | ||
| 50 | RS INVESTMENT MANAGEMENT CO LLC | 57,660 | 2,346,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
