| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Crestline Management, LP | 25,948,799 | 1,132,937,000 | 42.66% | ||
| 2 | FMR LLC | 7,293,224 | 320,683,000 | 12.08% | ||
| 3 | VANGUARD GROUP INC | 4,615,355 | 202,937,000 | 7.64% | ||
| 4 | Capital World Investors | 3,757,501 | 165,217,000 | 6.22% | ||
| 5 | FIRST TRUST ADVISORS LP | 2,068,290 | 90,943,000 | 3.42% | ||
| 6 | BIOMARK CAPITAL MANAGEMENT CO. LLC | 1,602,562 | 70,465,000 | 2.65% | ||
| 7 | BlackRock Fund Advisors | 1,329,599 | 58,462,000 | 2.20% | ||
| 8 | BB BIOTECH AG | 1,305,000 | 57,381,000 | 2.16% | ||
| 9 | Omega Fund Management, LLC | 1,229,512 | 54,062,000 | 2.04% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,200,737 | 52,796,000 | 1.99% | ||
| 11 | STATE STREET CORP | 1,008,449 | 44,344,000 | 1.67% | ||
| 12 | Temasek Holdings (Private) Ltd | 915,750 | 40,266,000 | 1.52% | ||
| 13 | NORGES BANK | 468,600 | 20,604,000 | 0.78% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 406,456 | 17,871,000 | 0.67% | ||
| 15 | LORD, ABBETT & CO. LLC | 391,693 | 17,223,000 | 0.65% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 384,700 | 16,915,000 | 0.64% | Put | |
| 17 | ArrowMark Colorado Holdings LLC | 383,749 | 16,873,000 | 0.64% | ||
| 18 | GOLDMAN SACHS GROUP INC | 334,288 | 14,699,000 | 0.55% | ||
| 19 | BAILLIE GIFFORD & CO | 280,000 | 12,312,000 | 0.46% | ||
| 20 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 270,651 | 11,901,000 | 0.45% | ||
| 21 | MORGAN STANLEY | 267,210 | 11,750,000 | 0.44% | ||
| 22 | BAMCO INC /NY/ | 200,000 | 8,794,000 | 0.33% | ||
| 23 | Rock Springs Capital Management LP | 197,001 | 8,662,000 | 0.33% | ||
| 24 | Artal Group S.A. | 190,000 | 8,354,000 | 0.31% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 184,508 | 8,113,000 | 0.31% | ||
| 26 | Tekla Capital Management LLC | 182,000 | 8,003,000 | 0.30% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 168,525 | 7,410,000 | 0.28% | ||
| 28 | PFM Health Sciences, LP | 150,684 | 6,626,000 | 0.25% | ||
| 29 | Bank of New York Mellon Corp | 146,514 | 6,441,000 | 0.24% | ||
| 30 | NORTHERN TRUST CORP | 140,663 | 6,185,000 | 0.23% | ||
| 31 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 135,422 | 5,955,000 | 0.22% | ||
| 32 | FRED ALGER MANAGEMENT, LLC | 135,310 | 5,950,000 | 0.22% | ||
| 33 | UBS Group AG | 133,279 | 5,861,000 | 0.22% | ||
| 34 | Zurcher Kantonalbank (Zurich Cantonalbank) | 130,233 | 5,726,000 | 0.22% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 122,259 | 5,376,000 | 0.20% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,000 | 4,925,000 | 0.19% | Call | |
| 37 | GOLDMAN SACHS GROUP INC | 110,100 | 4,841,000 | 0.18% | Put | |
| 38 | CLARIUS GROUP, LLC | 109,471 | 4,813,000 | 0.18% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 105,700 | 4,648,000 | 0.18% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 94,109 | 4,138,000 | 0.16% | ||
| 41 | EVENTIDE ASSET MANAGEMENT, LLC | 90,000 | 3,957,000 | 0.15% | ||
| 42 | HSBC HOLDINGS PLC | 88,830 | 3,905,000 | 0.15% | ||
| 43 | US BANCORP \DE\ | 88,700 | 3,900,000 | 0.15% | ||
| 44 | ProShare Advisors LLC | 83,550 | 3,674,000 | 0.14% | ||
| 45 | BAKER BROS. ADVISORS LP | 80,000 | 3,518,000 | 0.13% | ||
| 46 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 77,890 | 3,425,000 | 0.13% | ||
| 47 | CITIGROUP INC | 71,889 | 3,161,000 | 0.12% | ||
| 48 | SUFFOLK CAPITAL MANAGEMENT LLC | 68,848 | 3,027,000 | 0.11% | ||
| 49 | PRICE T ROWE ASSOCIATES INC /MD/ | 66,929 | 2,943,000 | 0.11% | ||
| 50 | Parametric Risk Advisors LLC | 65,000 | 2,858,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
