| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Crestline Management, LP | 17,348,799 | 327,025,000 | 24.94% | ||
| 2 | BAILLIE GIFFORD & CO | 11,061,955 | 208,518,000 | 15.90% | ||
| 3 | VANGUARD GROUP INC | 5,849,900 | 110,271,000 | 8.41% | ||
| 4 | STATE STREET CORP | 3,415,744 | 64,380,000 | 4.91% | ||
| 5 | Capital World Investors | 2,175,501 | 41,008,000 | 3.13% | ||
| 6 | BIOMARK CAPITAL MANAGEMENT CO. LLC | 2,168,601 | 40,878,000 | 3.12% | ||
| 7 | BlackRock Fund Advisors | 2,146,963 | 40,470,000 | 3.09% | ||
| 8 | FMR LLC | 1,918,592 | 36,165,000 | 2.76% | ||
| 9 | BB BIOTECH AG | 1,870,000 | 35,250,000 | 2.69% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,830,981 | 34,514,000 | 2.63% | ||
| 11 | SCOPIA CAPITAL MANAGEMENT LP | 1,778,724 | 33,529,000 | 2.56% | ||
| 12 | Omega Fund Management, LLC | 1,229,512 | 23,176,000 | 1.77% | ||
| 13 | MORGAN STANLEY | 961,187 | 18,119,000 | 1.38% | ||
| 14 | Mitsubishi UFJ Trust & Banking Corp | 948,320 | 17,876,000 | 1.36% | ||
| 15 | FIRST TRUST ADVISORS LP | 936,683 | 17,656,000 | 1.35% | ||
| 16 | Temasek Holdings (Private) Ltd | 915,750 | 17,262,000 | 1.32% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 903,100 | 17,023,000 | 1.30% | Put | |
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 810,718 | 15,282,000 | 1.17% | ||
| 19 | ArrowMark Colorado Holdings LLC | 788,720 | 14,867,000 | 1.13% | ||
| 20 | NORGES BANK | 742,341 | 13,993,000 | 1.07% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 546,620 | 10,303,000 | 0.79% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 434,662 | 8,193,000 | 0.62% | ||
| 23 | AMERIPRISE FINANCIAL INC | 358,995 | 6,766,000 | 0.52% | ||
| 24 | PICTET ASSET MANAGEMENT LTD | 337,478 | 6,362,000 | 0.49% | ||
| 25 | NORTHERN TRUST CORP | 281,837 | 5,312,000 | 0.41% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 269,346 | 5,078,000 | 0.39% | ||
| 27 | CITIGROUP INC | 256,940 | 4,844,000 | 0.37% | ||
| 28 | Bank of New York Mellon Corp | 255,636 | 4,819,000 | 0.37% | ||
| 29 | BROWN ADVISORY INC | 250,435 | 4,721,000 | 0.36% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 222,500 | 4,194,000 | 0.32% | Call | |
| 31 | DEUTSCHE BANK AG\ | 217,245 | 4,093,000 | 0.31% | ||
| 32 | D.A. DAVIDSON & CO. | 216,051 | 4,072,000 | 0.31% | ||
| 33 | Artal Group S.A. | 200,000 | 3,770,000 | 0.29% | ||
| 34 | AQR CAPITAL MANAGEMENT LLC | 199,463 | 3,760,000 | 0.29% | ||
| 35 | Rock Springs Capital Management LP | 197,001 | 3,713,000 | 0.28% | ||
| 36 | CREDIT SUISSE AG/ | 192,806 | 3,634,000 | 0.28% | ||
| 37 | UBS Group AG | 188,024 | 3,544,000 | 0.27% | ||
| 38 | Spark Investment Management LLC | 181,600 | 3,423,000 | 0.26% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 180,632 | 3,405,000 | 0.26% | ||
| 40 | GROUP ONE TRADING LLC | 154,519 | 2,913,000 | 0.22% | ||
| 41 | GOLDMAN SACHS GROUP INC | 148,651 | 2,802,000 | 0.21% | ||
| 42 | GUGGENHEIM CAPITAL LLC | 146,738 | 2,766,000 | 0.21% | ||
| 43 | ARK INVESTMENT MANAGEMENT LLC | 141,976 | 2,676,000 | 0.20% | ||
| 44 | Parallax Volatility Advisers, L.P. | 140,000 | 2,639,000 | 0.20% | Call | |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 130,805 | 2,466,000 | 0.19% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 126,700 | 2,388,000 | 0.18% | ||
| 47 | PFM Health Sciences, LP | 119,668 | 2,256,000 | 0.17% | ||
| 48 | CLARIUS GROUP, LLC | 117,896 | 2,222,000 | 0.17% | ||
| 49 | Clearline Capital LP | 116,200 | 2,190,000 | 0.17% | ||
| 50 | Swiss National Bank | 104,300 | 1,966,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
