| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Crestline Management, LP | 27,084,525 | 1,414,354,000 | 59.66% | ||
| 2 | FMR LLC | 5,235,467 | 273,396,000 | 11.53% | ||
| 3 | Capital World Investors | 2,132,501 | 79,420,000 | 3.35% | ||
| 4 | Omega Fund Management, LLC | 1,425,000 | 74,414,000 | 3.14% | ||
| 5 | VHCP Management, LLC | 1,749,999 | 74,326,000 | 3.14% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,150,084 | 58,917,000 | 2.49% | ||
| 7 | Temasek Holdings (Private) Ltd | 915,750 | 47,820,000 | 2.02% | ||
| 8 | AMERIPRISE FINANCIAL INC | 700,001 | 36,549,000 | 1.54% | ||
| 9 | PFM Health Sciences, LP | 631,042 | 32,953,000 | 1.39% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 358,149 | 18,703,000 | 0.79% | ||
| 11 | FRANKLIN RESOURCES INC | 321,100 | 16,768,000 | 0.71% | ||
| 12 | ALLIANCEBERNSTEIN L.P. | 319,521 | 16,685,000 | 0.70% | ||
| 13 | RA CAPITAL MANAGEMENT, L.P. | 280,000 | 14,622,000 | 0.62% | ||
| 14 | MORGAN STANLEY | 250,516 | 13,081,000 | 0.55% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 243,460 | 12,713,000 | 0.54% | ||
| 16 | ArrowMark Colorado Holdings LLC | 227,494 | 11,880,000 | 0.50% | ||
| 17 | MARSICO CAPITAL MANAGEMENT LLC | 175,067 | 9,142,000 | 0.39% | ||
| 18 | COLUMBUS CIRCLE INVESTORS | 155,842 | 8,138,000 | 0.34% | ||
| 19 | Invesco Ltd. | 150,000 | 7,833,000 | 0.33% | ||
| 20 | Rock Springs Capital Management LP | 144,426 | 7,542,000 | 0.32% | ||
| 21 | BLACKROCK ADVISORS LLC | 128,500 | 6,710,000 | 0.28% | ||
| 22 | Allianz Asset Management GmbH | 115,650 | 6,039,000 | 0.25% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 110,410 | 5,766,000 | 0.24% | ||
| 24 | DSAM Partners (London) Ltd | 103,544 | 5,407,000 | 0.23% | ||
| 25 | Artal Group S.A. | 100,000 | 5,222,000 | 0.22% | ||
| 26 | BAKER BROS. ADVISORS LP | 100,000 | 5,222,000 | 0.22% | ||
| 27 | BROWN ADVISORY INC | 97,944 | 5,115,000 | 0.22% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 97,400 | 5,086,000 | 0.21% | ||
| 29 | UBS Group AG | 96,612 | 5,045,000 | 0.21% | ||
| 30 | Foresite Capital Management II, LLC | 91,575 | 4,782,000 | 0.20% | ||
| 31 | FRED ALGER MANAGEMENT, LLC | 81,698 | 4,266,000 | 0.18% | ||
| 32 | LAZARD ASSET MANAGEMENT LLC | 81,260 | 4,243,000 | 0.18% | ||
| 33 | VANGUARD GROUP INC | 70,000 | 3,655,000 | 0.15% | ||
| 34 | Duquesne Family Office LLC | 70,000 | 3,655,000 | 0.15% | ||
| 35 | MARSHALL WACE, LLP | 62,514 | 3,264,000 | 0.14% | ||
| 36 | WADDELL & REED FINANCIAL INC | 62,400 | 3,259,000 | 0.14% | ||
| 37 | TUDOR INVESTMENT CORP ET AL | 60,631 | 3,166,000 | 0.13% | ||
| 38 | CITADEL ADVISORS LLC | 50,837 | 2,655,000 | 0.11% | ||
| 39 | DekaBank Deutsche Girozentrale | 48,700 | 2,640,000 | 0.11% | ||
| 40 | OppenheimerFunds, Inc. | 50,000 | 2,611,000 | 0.11% | ||
| 41 | ONTARIO TEACHERS PENSION PLAN BOARD | 50,000 | 2,611,000 | 0.11% | ||
| 42 | Omega Advisors Inc. | 50,000 | 2,611,000 | 0.11% | ||
| 43 | PERCEPTIVE ADVISORS LLC | 50,000 | 2,611,000 | 0.11% | ||
| 44 | Laurion Capital Management LP | 50,000 | 2,611,000 | 0.11% | ||
| 45 | GILDER GAGNON HOWE & CO LLC | 49,557 | 2,588,000 | 0.11% | ||
| 46 | ARROWGRASS CAPITAL PARTNERS (US) LP | 46,791 | 2,443,000 | 0.10% | ||
| 47 | JPMORGAN CHASE & CO | 43,962 | 2,296,000 | 0.10% | ||
| 48 | Visium Asset Management, LP | 40,523 | 2,117,000 | 0.09% | ||
| 49 | Weiss Multi-Strategy Advisers LLC | 40,000 | 2,089,000 | 0.09% | ||
| 50 | PLATINUM INVESTMENT MANAGEMENT LTD | 40,000 | 2,088,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
