| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Crestline Management, LP | 17,348,799 | 666,888,000 | 24.72% | ||
| 2 | BAILLIE GIFFORD & CO | 10,843,672 | 416,831,000 | 15.45% | ||
| 3 | FMR LLC | 5,707,235 | 219,386,000 | 8.13% | ||
| 4 | VANGUARD GROUP INC | 5,471,650 | 210,331,000 | 7.80% | ||
| 5 | Capital World Investors | 3,635,302 | 139,741,000 | 5.18% | ||
| 6 | RIVERHEAD CAPITAL MANAGEMENT LLC | 715,361 | 86,772,000 | 3.22% | ||
| 7 | BlackRock Fund Advisors | 1,964,403 | 75,512,000 | 2.80% | ||
| 8 | BIOMARK CAPITAL MANAGEMENT CO. LLC | 2,205,926 | 68,516,000 | 2.54% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,663,180 | 63,933,000 | 2.37% | ||
| 10 | STATE STREET CORP | 1,658,792 | 63,764,000 | 2.36% | ||
| 11 | BB BIOTECH AG | 1,305,000 | 50,164,000 | 1.86% | ||
| 12 | Omega Fund Management, LLC | 1,229,512 | 47,262,000 | 1.75% | ||
| 13 | MORGAN STANLEY | 1,149,502 | 44,186,000 | 1.64% | ||
| 14 | Mitsubishi UFJ Trust & Banking Corp | 959,230 | 36,873,000 | 1.37% | ||
| 15 | Temasek Holdings (Private) Ltd | 915,750 | 35,201,000 | 1.30% | ||
| 16 | FIRST TRUST ADVISORS LP | 703,197 | 27,031,000 | 1.00% | ||
| 17 | LORD, ABBETT & CO. LLC | 688,876 | 26,480,000 | 0.98% | ||
| 18 | NORGES BANK | 580,053 | 22,297,000 | 0.83% | ||
| 19 | ArrowMark Colorado Holdings LLC | 526,717 | 20,247,000 | 0.75% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 500,100 | 19,224,000 | 0.71% | Put | |
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 497,300 | 19,116,000 | 0.71% | ||
| 22 | AMERIPRISE FINANCIAL INC | 383,023 | 14,724,000 | 0.55% | ||
| 23 | DEUTSCHE BANK AG\ | 360,489 | 13,854,000 | 0.51% | ||
| 24 | GOLDMAN SACHS GROUP INC | 330,423 | 12,702,000 | 0.47% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 323,062 | 12,419,000 | 0.46% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 320,800 | 12,332,000 | 0.46% | Call | |
| 27 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 270,832 | 10,410,000 | 0.39% | ||
| 28 | NORTHERN TRUST CORP | 268,553 | 10,323,000 | 0.38% | ||
| 29 | Bank of New York Mellon Corp | 259,047 | 9,959,000 | 0.37% | ||
| 30 | SANDLER CAPITAL MANAGEMENT | 250,000 | 9,610,000 | 0.36% | Call | |
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 234,448 | 9,013,000 | 0.33% | ||
| 32 | AQR CAPITAL MANAGEMENT LLC | 232,432 | 8,935,000 | 0.33% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 180,438 | 7,836,000 | 0.29% | ||
| 34 | Artal Group S.A. | 200,000 | 7,688,000 | 0.28% | ||
| 35 | Rock Springs Capital Management LP | 197,001 | 7,573,000 | 0.28% | ||
| 36 | Tekla Capital Management LLC | 182,000 | 6,996,000 | 0.26% | ||
| 37 | Allianz Asset Management GmbH | 165,250 | 6,352,000 | 0.24% | ||
| 38 | ALPS ADVISORS INC | 145,751 | 5,603,000 | 0.21% | ||
| 39 | Zurcher Kantonalbank (Zurich Cantonalbank) | 134,849 | 5,184,000 | 0.19% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 133,205 | 5,120,000 | 0.19% | ||
| 41 | CLARIUS GROUP, LLC | 114,396 | 4,937,000 | 0.18% | ||
| 42 | CREDIT SUISSE AG/ | 123,916 | 4,762,000 | 0.18% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 123,865 | 4,761,000 | 0.18% | ||
| 44 | Parallax Volatility Advisers, L.P. | 123,000 | 4,728,000 | 0.18% | Call | |
| 45 | PEAK6 Group LLC | 119,800 | 4,605,000 | 0.17% | Call | |
| 46 | Jefferies Group LLC | 116,600 | 4,482,000 | 0.17% | Call | |
| 47 | GUGGENHEIM CAPITAL LLC | 115,404 | 4,436,000 | 0.16% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101,172 | 3,889,000 | 0.14% | ||
| 49 | BAMCO INC /NY/ | 100,525 | 3,864,000 | 0.14% | ||
| 50 | MACQUARIE GROUP LTD | 99,167 | 3,812,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
