| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Crestline Management, LP | 27,084,525 | 1,642,947,000 | 55.13% | ||
| 2 | FMR LLC | 6,428,631 | 389,961,000 | 13.08% | ||
| 3 | Capital World Investors | 3,243,251 | 176,738,000 | 5.93% | ||
| 4 | VHCP Management, LLC | 1,749,999 | 96,955,000 | 3.25% | ||
| 5 | Omega Fund Management, LLC | 1,375,000 | 83,407,000 | 2.80% | ||
| 6 | VANGUARD GROUP INC | 1,353,132 | 82,081,000 | 2.75% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 1,007,324 | 61,104,000 | 2.05% | ||
| 8 | Temasek Holdings (Private) Ltd | 915,750 | 55,549,000 | 1.86% | ||
| 9 | LORD, ABBETT & CO. LLC | 712,803 | 43,239,000 | 1.45% | ||
| 10 | PFM Health Sciences, LP | 514,585 | 30,488,000 | 1.02% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 411,170 | 24,942,000 | 0.84% | ||
| 12 | ArrowMark Colorado Holdings LLC | 294,527 | 17,866,000 | 0.60% | ||
| 13 | RS INVESTMENT MANAGEMENT CO LLC | 289,790 | 17,579,000 | 0.59% | ||
| 14 | RA CAPITAL MANAGEMENT, L.P. | 280,000 | 16,985,000 | 0.57% | ||
| 15 | Allianz Asset Management GmbH | 247,153 | 14,993,000 | 0.50% | ||
| 16 | COLUMBUS CIRCLE INVESTORS | 232,031 | 14,075,000 | 0.47% | ||
| 17 | MARSICO CAPITAL MANAGEMENT LLC | 226,302 | 13,728,000 | 0.46% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 188,300 | 11,422,000 | 0.38% | Put | |
| 19 | DEERFIELD MANAGEMENT COMPANY, L.P. | 183,149 | 11,110,000 | 0.37% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 155,129 | 9,410,000 | 0.32% | ||
| 21 | AMERIPRISE FINANCIAL INC | 150,035 | 9,103,000 | 0.31% | ||
| 22 | UBS Group AG | 134,683 | 8,170,000 | 0.27% | ||
| 23 | Artal Group S.A. | 130,000 | 7,886,000 | 0.26% | ||
| 24 | Rock Springs Capital Management LP | 122,426 | 7,426,000 | 0.25% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 108,400 | 6,576,000 | 0.22% | Call | |
| 26 | SOROS FUND MANAGEMENT LLC | 105,500 | 6,400,000 | 0.21% | ||
| 27 | MORGAN STANLEY | 101,644 | 6,165,000 | 0.21% | ||
| 28 | BAKER BROS. ADVISORS LP | 100,000 | 6,066,000 | 0.20% | ||
| 29 | Foresite Capital Management II, LLC | 91,575 | 5,555,000 | 0.19% | ||
| 30 | FRED ALGER MANAGEMENT, LLC | 81,628 | 4,952,000 | 0.17% | ||
| 31 | BlackRock Fund Advisors | 76,903 | 4,665,000 | 0.16% | ||
| 32 | GUGGENHEIM CAPITAL LLC | 75,300 | 4,568,000 | 0.15% | ||
| 33 | GILDER GAGNON HOWE & CO LLC | 74,799 | 4,537,000 | 0.15% | ||
| 34 | STATE STREET CORP | 71,931 | 4,361,000 | 0.15% | ||
| 35 | Laurion Capital Management LP | 67,200 | 4,076,000 | 0.14% | ||
| 36 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 65,450 | 3,970,000 | 0.13% | ||
| 37 | DSAM Partners (London) Ltd | 62,822 | 3,811,000 | 0.13% | ||
| 38 | JPMORGAN CHASE & CO | 58,883 | 3,572,000 | 0.12% | ||
| 39 | Informed Momentum Co LLC | 56,704 | 3,440,000 | 0.12% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,240 | 3,412,000 | 0.11% | ||
| 41 | OppenheimerFunds, Inc. | 50,670 | 3,074,000 | 0.10% | ||
| 42 | Omega Advisors Inc. | 50,000 | 3,033,000 | 0.10% | ||
| 43 | Bank of New York Mellon Corp | 49,527 | 3,004,000 | 0.10% | ||
| 44 | GLG LLC | 47,345 | 2,872,000 | 0.10% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,113 | 2,737,000 | 0.09% | ||
| 46 | NORTHERN TRUST CORP | 40,539 | 2,459,000 | 0.08% | ||
| 47 | PLATINUM INVESTMENT MANAGEMENT LTD | 40,000 | 2,426,000 | 0.08% | ||
| 48 | JANE STREET GROUP, LLC | 34,523 | 2,094,000 | 0.07% | ||
| 49 | AXA S.A. | 32,279 | 1,958,000 | 0.07% | ||
| 50 | BENNETT LAWRENCE MANAGEMENT L L C/NY | 30,000 | 1,820,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
