| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Crestline Management, LP | 25,988,799 | 1,385,983,000 | 52.90% | ||
| 2 | FMR LLC | 6,576,290 | 350,714,000 | 13.39% | ||
| 3 | Capital World Investors | 3,782,501 | 201,721,000 | 7.70% | ||
| 4 | VANGUARD GROUP INC | 1,397,829 | 74,546,000 | 2.85% | ||
| 5 | Omega Fund Management, LLC | 1,375,000 | 73,329,000 | 2.80% | ||
| 6 | Temasek Holdings (Private) Ltd | 915,750 | 48,837,000 | 1.86% | ||
| 7 | LORD, ABBETT & CO. LLC | 638,325 | 34,042,000 | 1.30% | ||
| 8 | STATE STREET CORP | 532,372 | 28,391,000 | 1.08% | ||
| 9 | JPMORGAN CHASE & CO | 455,046 | 24,267,000 | 0.93% | ||
| 10 | BB BIOTECH AG | 450,000 | 23,999,000 | 0.92% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 423,093 | 22,564,000 | 0.86% | ||
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 389,200 | 20,756,000 | 0.79% | Put | |
| 13 | CITADEL ADVISORS LLC | 359,011 | 19,146,000 | 0.73% | ||
| 14 | ArrowMark Colorado Holdings LLC | 335,261 | 17,879,000 | 0.68% | ||
| 15 | REGENTATLANTIC CAPITAL LLC | 222 | 17,469,000 | 0.67% | ||
| 16 | RA CAPITAL MANAGEMENT, L.P. | 280,000 | 14,932,000 | 0.57% | ||
| 17 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 270,675 | 14,435,000 | 0.55% | ||
| 18 | Rock Springs Capital Management LP | 197,000 | 10,506,000 | 0.40% | ||
| 19 | Artal Group S.A. | 190,000 | 10,133,000 | 0.39% | ||
| 20 | DEERFIELD MANAGEMENT COMPANY, L.P. | 183,149 | 9,767,000 | 0.37% | ||
| 21 | GUGGENHEIM CAPITAL LLC | 180,703 | 9,637,000 | 0.37% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 157,947 | 8,423,000 | 0.32% | ||
| 23 | MORGAN STANLEY | 134,703 | 7,183,000 | 0.27% | ||
| 24 | GRATICULE ASIA MACRO ADVISORS LLC | 126,500 | 6,747,000 | 0.26% | ||
| 25 | PFM Health Sciences, LP | 118,954 | 6,344,000 | 0.24% | ||
| 26 | AMERIPRISE FINANCIAL INC | 108,467 | 5,784,000 | 0.22% | ||
| 27 | CITIGROUP INC | 107,900 | 5,755,000 | 0.22% | Put | |
| 28 | MARSICO CAPITAL MANAGEMENT LLC | 105,434 | 5,623,000 | 0.21% | ||
| 29 | PDT Partners, LLC | 102,658 | 5,475,000 | 0.21% | ||
| 30 | PRICE T ROWE ASSOCIATES INC /MD/ | 98,100 | 5,232,000 | 0.20% | ||
| 31 | JANE STREET GROUP, LLC | 97,000 | 5,173,000 | 0.20% | Call | |
| 32 | BlackRock Fund Advisors | 91,904 | 4,901,000 | 0.19% | ||
| 33 | Foresite Capital Management II, LLC | 91,575 | 4,884,000 | 0.19% | ||
| 34 | VHCP Management, LLC | 90,206 | 4,811,000 | 0.18% | ||
| 35 | HSBC HOLDINGS PLC | 88,404 | 4,714,000 | 0.18% | ||
| 36 | FRED ALGER MANAGEMENT, LLC | 88,112 | 4,699,000 | 0.18% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 85,100 | 4,538,000 | 0.17% | Call | |
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,518 | 4,401,000 | 0.17% | ||
| 39 | BAKER BROS. ADVISORS LP | 80,000 | 4,266,000 | 0.16% | ||
| 40 | HIGHLAND CAPITAL MANAGEMENT LP | 80,000 | 4,266,000 | 0.16% | ||
| 41 | GLG LLC | 74,228 | 3,959,000 | 0.15% | ||
| 42 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 66,145 | 3,528,000 | 0.13% | ||
| 43 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 64,481 | 3,439,000 | 0.13% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,600 | 3,232,000 | 0.12% | Call | |
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 58,575 | 3,124,000 | 0.12% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 56,663 | 3,022,000 | 0.12% | ||
| 47 | CREDIT SUISSE AG/ | 56,151 | 2,995,000 | 0.11% | ||
| 48 | GSA CAPITAL PARTNERS LLP | 54,700 | 2,917,000 | 0.11% | ||
| 49 | NORTHERN TRUST CORP | 52,733 | 2,812,000 | 0.11% | ||
| 50 | GROUP ONE TRADING LLC | 49,031 | 2,615,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
