| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,256,239 | 21,184,000 | 28.18% | ||
| 2 | Capital World Investors | 659,497 | 11,122,000 | 14.80% | ||
| 3 | Visium Asset Management, LP | 475,000 | 8,011,000 | 10.66% | ||
| 4 | Invesco Private Capital, Inc. | 444,655 | 7,626,000 | 10.15% | ||
| 5 | BVF INC/IL | 391,424 | 6,601,000 | 8.78% | ||
| 6 | ROYAL BANK OF CANADA | 330,202 | 5,569,000 | 7.41% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 225,000 | 3,795,000 | 5.05% | ||
| 8 | EcoR1 Capital, LLC | 220,570 | 3,720,000 | 4.95% | ||
| 9 | Ativo Capital Management LLC | 137,389 | 2,317,000 | 3.08% | ||
| 10 | Novo Holdings A/S | 127,563 | 2,151,000 | 2.86% | ||
| 11 | Point72 Asset Management, L.P. | 110,000 | 1,855,000 | 2.47% | ||
| 12 | CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 22,479 | 379,000 | 0.50% | ||
| 13 | GSA CAPITAL PARTNERS LLP | 12,300 | 207,000 | 0.28% | ||
| 14 | GOLDMAN SACHS GROUP INC | 11,999 | 202,000 | 0.27% | ||
| 15 | Spark Investment Management LLC | 11,296 | 188,000 | 0.25% | ||
| 16 | ACADIAN ASSET MANAGEMENT LLC | 3,889 | 65,000 | 0.09% | ||
| 17 | BANK OF AMERICA CORP /DE/ | 3,033 | 51,000 | 0.07% | ||
| 18 | WELLS FARGO & COMPANY/MN | 2,464 | 42,000 | 0.06% | ||
| 19 | Cubist Systematic Strategies, LLC | 2,089 | 35,000 | 0.05% | ||
| 20 | Winslow, Evans & Crocker, Inc. | 1,086 | 18,316 | 0.02% | ||
| 21 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,000 | 17,000 | 0.02% | ||
| 22 | UBS Group AG | 346 | 6,000 | 0.01% | ||
| 23 | MORGAN STANLEY | 324 | 5,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
