| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 3,043,805 | 23,437,000 | 29.01% | ||
| 2 | Capital World Investors | 1,225,000 | 9,433,000 | 11.67% | ||
| 3 | ORBIMED ADVISORS LLC | 1,000,000 | 7,700,000 | 9.53% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 740,272 | 5,700,000 | 7.05% | ||
| 5 | Tekla Capital Management LLC | 700,000 | 5,390,000 | 6.67% | ||
| 6 | DAFNA Capital Management LLC | 514,091 | 3,959,000 | 4.90% | ||
| 7 | Opaleye Management Inc. | 405,000 | 3,119,000 | 3.86% | ||
| 8 | Invesco Private Capital, Inc. | 400,677 | 3,085,000 | 3.82% | ||
| 9 | SPHERA FUNDS MANAGEMENT LTD. | 328,029 | 2,526,000 | 3.13% | ||
| 10 | Ghost Tree Capital, LLC | 325,000 | 2,503,000 | 3.10% | ||
| 11 | INTERWEST VENTURE MANAGEMENT CO | 320,061 | 2,465,000 | 3.05% | ||
| 12 | Point72 Asset Management, L.P. | 310,179 | 2,388,000 | 2.96% | ||
| 13 | ROYAL BANK OF CANADA | 246,277 | 1,897,000 | 2.35% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 193,674 | 1,491,000 | 1.85% | ||
| 15 | Novo Holdings A/S | 127,563 | 982,000 | 1.22% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 114,200 | 879,000 | 1.09% | ||
| 17 | HIGHLAND CAPITAL MANAGEMENT LP | 110,213 | 848,000 | 1.05% | ||
| 18 | ESSEX INVESTMENT MANAGEMENT CO LLC | 70,172 | 540,000 | 0.67% | ||
| 19 | State of New Jersey Common Pension Fund D | 65,000 | 501,000 | 0.62% | ||
| 20 | K2 PRINCIPAL FUND, L.P. | 57,228 | 441,000 | 0.55% | ||
| 21 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 55,000 | 424,000 | 0.52% | ||
| 22 | PRELUDE CAPITAL MANAGEMENT, LLC | 34,928 | 269,000 | 0.33% | ||
| 23 | Weiss Multi-Strategy Advisers LLC | 31,500 | 243,000 | 0.30% | ||
| 24 | SCOTIA CAPITAL INC. | 20,818 | 160,000 | 0.20% | ||
| 25 | NJ State Employees Deferred Compensation Plan | 20,000 | 154,000 | 0.19% | ||
| 26 | DEUTSCHE BANK AG\ | 12,762 | 98,000 | 0.12% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 10,020 | 77,000 | 0.10% | ||
| 28 | BANK OF MONTREAL /CAN/ | 7,137 | 56,000 | 0.07% | ||
| 29 | WELLS FARGO & COMPANY/MN | 2,514 | 19,000 | 0.02% | ||
| 30 | MORGAN STANLEY | 1,136 | 9,000 | 0.01% | ||
| 31 | CITIGROUP INC | 700 | 5,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
