| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,141,062 | 13,157,000 | 23.74% | ||
| 2 | BVF INC/IL | 678,764 | 7,826,000 | 14.12% | ||
| 3 | Capital World Investors | 659,497 | 7,604,000 | 13.72% | ||
| 4 | ROYAL BANK OF CANADA | 467,003 | 5,385,000 | 9.72% | ||
| 5 | Visium Asset Management, LP | 450,000 | 5,189,000 | 9.36% | ||
| 6 | Invesco Private Capital, Inc. | 444,655 | 5,127,000 | 9.25% | ||
| 7 | Point72 Asset Management, L.P. | 267,340 | 3,082,000 | 5.56% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 225,000 | 2,594,000 | 4.68% | ||
| 9 | Novo Holdings A/S | 127,563 | 1,471,000 | 2.65% | ||
| 10 | EcoR1 Capital, LLC | 73,000 | 842,000 | 1.52% | ||
| 11 | State of New Jersey Common Pension Fund D | 65,000 | 749,000 | 1.35% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 42,000 | 484,000 | 0.87% | ||
| 13 | Ghost Tree Capital, LLC | 37,500 | 432,000 | 0.78% | ||
| 14 | GSA CAPITAL PARTNERS LLP | 33,244 | 383,000 | 0.69% | ||
| 15 | ACADIAN ASSET MANAGEMENT LLC | 22,126 | 255,000 | 0.46% | ||
| 16 | DEUTSCHE BANK AG\ | 21,126 | 243,000 | 0.44% | ||
| 17 | NJ State Employees Deferred Compensation Plan | 20,000 | 231,000 | 0.42% | ||
| 18 | Spark Investment Management LLC | 10,300 | 118,000 | 0.21% | ||
| 19 | BANK OF MONTREAL /CAN/ | 9,037 | 105,000 | 0.19% | ||
| 20 | Cubist Systematic Strategies, LLC | 3,178 | 37,000 | 0.07% | ||
| 21 | MORGAN STANLEY | 2,829 | 33,000 | 0.06% | ||
| 22 | WELLS FARGO & COMPANY/MN | 2,614 | 30,000 | 0.05% | ||
| 23 | PRELUDE CAPITAL MANAGEMENT, LLC | 2,600 | 30,000 | 0.05% | ||
| 24 | UBS Group AG | 1,058 | 12,000 | 0.02% | ||
| 25 | Tower Research Capital LLC (TRC) | 100 | 1,000 | 0.00% | ||
| 26 | CITIGROUP INC | 51 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
