| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 1,035,572 | 8,554,000 | 18.91% | ||
| 2 | Capital World Investors | 1,030,000 | 8,508,000 | 18.81% | ||
| 3 | FMR LLC | 910,920 | 7,524,000 | 16.63% | ||
| 4 | ROYAL BANK OF CANADA | 468,289 | 3,868,000 | 8.55% | ||
| 5 | Invesco Private Capital, Inc. | 444,655 | 3,673,000 | 8.12% | ||
| 6 | Visium Asset Management, LP | 440,000 | 3,634,000 | 8.03% | ||
| 7 | Point72 Asset Management, L.P. | 317,385 | 2,622,000 | 5.80% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 205,800 | 1,699,000 | 3.76% | ||
| 9 | Opaleye Management Inc. | 151,300 | 1,250,000 | 2.76% | ||
| 10 | Novo Holdings A/S | 127,563 | 1,054,000 | 2.33% | ||
| 11 | JBF Capital, Inc. | 68,690 | 567,000 | 1.25% | ||
| 12 | GSA CAPITAL PARTNERS LLP | 65,941 | 545,000 | 1.20% | ||
| 13 | State of New Jersey Common Pension Fund D | 65,000 | 537,000 | 1.19% | ||
| 14 | Weiss Multi-Strategy Advisers LLC | 42,400 | 350,000 | 0.77% | ||
| 15 | DAFNA Capital Management LLC | 25,000 | 207,000 | 0.46% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 20,500 | 169,000 | 0.37% | ||
| 17 | NJ State Employees Deferred Compensation Plan | 20,000 | 165,000 | 0.36% | ||
| 18 | DEUTSCHE BANK AG\ | 11,885 | 98,000 | 0.22% | ||
| 19 | ACADIAN ASSET MANAGEMENT LLC | 10,474 | 86,000 | 0.19% | ||
| 20 | BANK OF MONTREAL /CAN/ | 8,037 | 66,000 | 0.15% | ||
| 21 | WELLS FARGO & COMPANY/MN | 2,264 | 19,000 | 0.04% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 2,182 | 18,000 | 0.04% | ||
| 23 | Cubist Systematic Strategies, LLC | 1,440 | 12,000 | 0.03% | ||
| 24 | Tower Research Capital LLC (TRC) | 935 | 8,000 | 0.02% | ||
| 25 | CITIGROUP INC | 700 | 6,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
