| 1 |
BVF INC/IL |
1,775,572 |
10,511,000 |
32.80% |
|
|
| 2 |
Capital World Investors |
1,030,000 |
6,098,000 |
19.03% |
|
|
| 3 |
Invesco Private Capital, Inc. |
436,384 |
2,575,000 |
8.03% |
|
|
| 4 |
PERCEPTIVE ADVISORS LLC |
432,800 |
2,553,000 |
7.97% |
|
|
| 5 |
Opaleye Management Inc. |
410,000 |
2,419,000 |
7.55% |
|
|
| 6 |
ROYAL BANK OF CANADA |
392,484 |
2,315,000 |
7.22% |
|
|
| 7 |
Point72 Asset Management, L.P. |
358,531 |
2,115,000 |
6.60% |
|
|
| 8 |
DAFNA Capital Management LLC |
214,091 |
1,263,000 |
3.94% |
|
|
| 9 |
Novo Holdings A/S |
127,563 |
753,000 |
2.35% |
|
|
| 10 |
State of New Jersey Common Pension Fund D |
65,000 |
385,000 |
1.20% |
|
|
| 11 |
LEITH WHEELER INVESTMENT COUNSEL LTD. |
17,869 |
370,000 |
1.15% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
48,500 |
286,000 |
0.89% |
|
|
| 13 |
Weiss Multi-Strategy Advisers LLC |
32,400 |
191,000 |
0.60% |
|
|
| 14 |
NJ State Employees Deferred Compensation Plan |
20,000 |
118,000 |
0.37% |
|
|
| 15 |
BANK OF MONTREAL /CAN/ |
7,137 |
42,000 |
0.13% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
3,646 |
21,000 |
0.07% |
|
|
| 17 |
WELLS FARGO & COMPANY/MN |
2,925 |
17,000 |
0.05% |
|
|
| 18 |
Tower Research Capital LLC (TRC) |
886 |
6,000 |
0.02% |
|
|
| 19 |
MORGAN STANLEY |
917 |
5,000 |
0.02% |
|
|
| 20 |
CITIGROUP INC |
700 |
4,000 |
0.01% |
|
|
| 21 |
JPMORGAN CHASE & CO |
111 |
1,000 |
0.00% |
|
|
| 22 |
WOLVERINE TRADING LP /BD |
71 |
423 |
0.00% |
|
|
